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1mx5

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{{Seed}}
 
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[[Image:1mx5.png|left|200px]]
 
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==Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue==
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The line below this paragraph, containing "STRUCTURE_1mx5", creates the "Structure Box" on the page.
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<StructureSection load='1mx5' size='340' side='right'caption='[[1mx5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mx5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MX5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HTQ:HOMOTROPINE'>HTQ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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{{STRUCTURE_1mx5| PDB=1mx5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mx5 OCA], [https://pdbe.org/1mx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mx5 RCSB], [https://www.ebi.ac.uk/pdbsum/1mx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mx5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EST1_HUMAN EST1_HUMAN] Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.<ref>PMID:7980644</ref> <ref>PMID:9169443</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/1mx5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mx5 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue===
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==See Also==
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*[[Carboxylesterase 3D structures|Carboxylesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12679808 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12679808}}
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==About this Structure==
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1MX5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX5 OCA].
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==Reference==
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Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR, Nat Struct Biol. 2003 May;10(5):349-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679808 12679808]
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[[Category: Carboxylesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bencharit, S.]]
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[[Category: Bencharit S]]
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[[Category: Morton, C L.]]
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[[Category: Morton CL]]
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[[Category: Potter, P M.]]
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[[Category: Potter PM]]
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[[Category: Redinbo, M R.]]
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[[Category: Redinbo MR]]
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[[Category: Xue, Y.]]
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[[Category: Xue Y]]
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[[Category: Cocaine]]
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[[Category: Esterase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:10:18 2008''
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Current revision

Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue

PDB ID 1mx5

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