2o81

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{{Seed}}
 
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[[Image:2o81.png|left|200px]]
 
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==The Structure of Tandem GA RNA Pairs When Flanking Pairs are isoG-isoC Pairs==
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The line below this paragraph, containing "STRUCTURE_2o81", creates the "Structure Box" on the page.
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<StructureSection load='2o81' size='340' side='right'caption='[[2o81]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2o81]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O81 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IC:ISOCYTIDINE-5-MONOPHOSPHATE'>IC</scene>, <scene name='pdbligand=IG:ISOGUANOSINE-5-MONOPHOSPHATE'>IG</scene></td></tr>
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{{STRUCTURE_2o81| PDB=2o81 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o81 OCA], [https://pdbe.org/2o81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o81 RCSB], [https://www.ebi.ac.uk/pdbsum/2o81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o81 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Watson-Crick-like isoG-isoC (iGiC) pair, with the amino and carbonyl groups transposed relative to the Watson-Crick GC pair, provides an expanded alphabet for understanding interactions that shape nucleic acid structure. Here, thermodynamic stabilities of tandem GA pairs flanked by iGiC pairs are reported along with the NMR structures of the RNA self-complementary duplexes (GCiGGAiCGCA)2 and (GGiCGAiGCCA)2. A sheared GA pairing forms in (GCiGGAiCGCA)2, and an imino GA pairing forms in (GGiCGAiGCCA)2. The structures contrast with the formation of tandem imino and sheared GA pairs flanked by GC pairs in the RNA self-complementary duplexes (GCGGACGC)2 and (GGCGAGCC)2, respectively. In both iGiC duplexes, Watson-Crick-like hydrogen bonds are formed between iG and iC, and iGiC substitutions result in less favorable loop stability. The results provide benchmarks for testing computations of molecular interactions that shape RNA three-dimensional structure.
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===The Structure of Tandem GA RNA Pairs When Flanking Pairs are isoG-isoC Pairs===
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Stacking effects on local structure in RNA: changes in the structure of tandem GA pairs when flanking GC pairs are replaced by isoG-isoC pairs.,Chen G, Kierzek R, Yildirim I, Krugh TR, Turner DH, Kennedy SD J Phys Chem B. 2007 Jun 21;111(24):6718-27. Epub 2007 Apr 6. PMID:17411085<ref>PMID:17411085</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17411085}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2o81" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17411085 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17411085}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O81 OCA].
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[[Category: Chen G]]
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[[Category: Turner DH]]
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==Reference==
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Stacking effects on local structure in RNA: changes in the structure of tandem GA pairs when flanking GC pairs are replaced by isoG-isoC pairs., Chen G, Kierzek R, Yildirim I, Krugh TR, Turner DH, Kennedy SD, J Phys Chem B. 2007 Jun 21;111(24):6718-27. Epub 2007 Apr 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17411085 17411085]
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[[Category: Chen, G.]]
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[[Category: Turner, D H.]]
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[[Category: Isocytidine]]
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[[Category: Isoguanosine]]
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[[Category: Rna]]
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[[Category: Secondary structure prediction]]
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[[Category: Sheared ga pair]]
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[[Category: Thermodynamic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:17:35 2008''
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Current revision

The Structure of Tandem GA RNA Pairs When Flanking Pairs are isoG-isoC Pairs

PDB ID 2o81

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