1jxz

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{{Seed}}
 
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[[Image:1jxz.png|left|200px]]
 
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==Structure of the H90Q mutant of 4-Chlorobenzoyl-Coenzyme A Dehalogenase complexed with 4-hydroxybenzoyl-Coenzyme A (product)==
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The line below this paragraph, containing "STRUCTURE_1jxz", creates the "Structure Box" on the page.
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<StructureSection load='1jxz' size='340' side='right'caption='[[1jxz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jxz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._CBS3 Pseudomonas sp. CBS3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCA:4-HYDROXYBENZOYL+COENZYME+A'>BCA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1jxz| PDB=1jxz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxz OCA], [https://pdbe.org/1jxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxz RCSB], [https://www.ebi.ac.uk/pdbsum/1jxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBADH_PSEUC CBADH_PSEUC] Dehalogenates 4-chlorobenzoyl-CoA, 4-iodobenzoyl-CoA and 4-bromobenzoyl-CoA, but not 4-fluorobenzoyl-CoA. Inactive towards crotonyl-CoA, alpha-methylcrotonyl-CoA and beta-methylcrotonyl-CoA.<ref>PMID:1610806</ref> <ref>PMID:7579994</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxz ConSurf].
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<div style="clear:both"></div>
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===Structure of the H90Q mutant of 4-Chlorobenzoyl-Coenzyme A Dehalogenase complexed with 4-hydroxybenzoyl-Coenzyme A (product)===
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==See Also==
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*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11695894 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11695894}}
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[[Category: Pseudomonas sp. CBS3]]
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[[Category: Benning MM]]
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==About this Structure==
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[[Category: Dunaway-Mariano D]]
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1JXZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXZ OCA].
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[[Category: Holden HM]]
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[[Category: Luo L]]
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==Reference==
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[[Category: Taylor KL]]
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Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis., Zhang W, Wei Y, Luo L, Taylor KL, Yang G, Dunaway-Mariano D, Benning MM, Holden HM, Biochemistry. 2001 Nov 13;40(45):13474-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11695894 11695894]
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[[Category: Thoden JB]]
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[[Category: 4-chlorobenzoate dehalogenase]]
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[[Category: Wei Y]]
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[[Category: Pseudomonas sp.]]
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[[Category: Yang G]]
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[[Category: Single protein]]
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[[Category: Zhang W]]
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[[Category: Benning, M M.]]
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[[Category: Dunaway-Mariano, D.]]
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[[Category: Holden, H M.]]
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[[Category: Luo, L.]]
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[[Category: Taylor, K L.]]
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[[Category: Thoden, J B.]]
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[[Category: Wei, Y.]]
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[[Category: Yang, G.]]
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[[Category: Zhang, W.]]
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[[Category: Coenzyme-a]]
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[[Category: Dehalogenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:17:41 2008''
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Current revision

Structure of the H90Q mutant of 4-Chlorobenzoyl-Coenzyme A Dehalogenase complexed with 4-hydroxybenzoyl-Coenzyme A (product)

PDB ID 1jxz

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