2atx

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{{Seed}}
 
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[[Image:2atx.png|left|200px]]
 
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==Crystal Structure of the TC10 GppNHp complex==
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The line below this paragraph, containing "STRUCTURE_2atx", creates the "Structure Box" on the page.
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<StructureSection load='2atx' size='340' side='right'caption='[[2atx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2atx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ATX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2atx| PDB=2atx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2atx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atx OCA], [https://pdbe.org/2atx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2atx RCSB], [https://www.ebi.ac.uk/pdbsum/2atx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2atx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHOQ_HUMAN RHOQ_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.<ref>PMID:15546864</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/2atx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2atx ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the TC10 GppNHp complex===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16246732 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16246732}}
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==About this Structure==
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2ATX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATX OCA].
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==Reference==
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An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins., Hemsath L, Dvorsky R, Fiegen D, Carlier MF, Ahmadian MR, Mol Cell. 2005 Oct 28;20(2):313-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16246732 16246732]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Small monomeric GTPase]]
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[[Category: Ahmadian MR]]
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[[Category: Ahmadian, M R.]]
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[[Category: Carlier MF]]
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[[Category: Carlier, M F.]]
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[[Category: Dvorsky R]]
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[[Category: Dvorsky, R.]]
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[[Category: Fiegen D]]
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[[Category: Fiegen, D.]]
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[[Category: Hemsath L]]
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[[Category: Hemsath, L.]]
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[[Category: Alpha-beta]]
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[[Category: Gtpase]]
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[[Category: P-loop]]
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[[Category: Tc10]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:22:38 2008''
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Current revision

Crystal Structure of the TC10 GppNHp complex

PDB ID 2atx

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OCA

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