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1shi

From Proteopedia

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{{Seed}}
 
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[[Image:1shi.png|left|200px]]
 
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<!--
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==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==
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The line below this paragraph, containing "STRUCTURE_1shi", creates the "Structure Box" on the page.
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<StructureSection load='1shi' size='340' side='right'caption='[[1shi]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1shi| PDB=1shi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [https://pdbe.org/1shi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [https://www.ebi.ac.uk/pdbsum/1shi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shi ProSAT]</span></td></tr>
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</table>
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===REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI===
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== Function ==
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[https://www.uniprot.org/uniprot/NA21_STIHL NA21_STIHL] Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (By similarity). Is highly toxic to crabs (by intrahemocoelic injection) (PubMed:2568126, PubMed:22015268), but without effect upon mice (by intraperitoneal injection) (PubMed:2568126).<ref>PMID:22015268</ref> <ref>PMID:2568126</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_7901218}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 7901218 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shi_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_7901218}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1SHI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shi ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Refined structure in solution of the sea anemone neurotoxin ShI., Wilcox GR, Fogh RH, Norton RS, J Biol Chem. 1993 Nov 25;268(33):24707-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7901218 7901218]
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<references/>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Stichodactyla helianthus]]
[[Category: Stichodactyla helianthus]]
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[[Category: Dyke, T R.]]
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[[Category: Dyke TR]]
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[[Category: Norton, R S.]]
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[[Category: Norton RS]]
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[[Category: Pallaghy, P K.]]
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[[Category: Pallaghy PK]]
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[[Category: Neurotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:23:36 2008''
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Current revision

REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI

PDB ID 1shi

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