1oy6

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(New page: 200px<br /><applet load="1oy6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oy6, resolution 3.68&Aring;" /> '''Structural Basis of ...)
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[[Image:1oy6.jpg|left|200px]]<br /><applet load="1oy6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1oy6, resolution 3.68&Aring;" />
 
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'''Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump'''<br />
 
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==Overview==
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==Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump==
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Multidrug efflux pumps cause serious problems in cancer chemotherapy and, treatment of bacterial infections. Yet high-resolution structures of, ligand transporter complexes have previously been unavailable. We obtained, x-ray crystallographic structures of the trimeric AcrB pump from, Escherichia coli with four structurally diverse ligands. The structures, show that three molecules of ligands bind simultaneously to the extremely, large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions. Each ligand uses a, slightly different subset of AcrB residues for binding. The bound ligand, molecules often interact with each other, stabilizing the binding.
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<StructureSection load='1oy6' size='340' side='right'caption='[[1oy6]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1oy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OY6 FirstGlance]. <br>
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1OY6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OY6 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oy6 OCA], [https://pdbe.org/1oy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1oy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oy6 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump., Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr, Science. 2003 May 9;300(5621):976-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12738864 12738864]
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== Function ==
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[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/1oy6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oy6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Jr., D.E.Koshland.]]
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[[Category: Koshland Jr DE]]
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[[Category: McDermott, G.]]
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[[Category: McDermott G]]
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[[Category: Nikaido, H.]]
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[[Category: Nikaido H]]
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[[Category: Yu, E.W.]]
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[[Category: Yu EW]]
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[[Category: Zgurskaya, H.I.]]
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[[Category: Zgurskaya HI]]
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[[Category: membrane protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:17:27 2007''
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Current revision

Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump

PDB ID 1oy6

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