1zp8

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{{Seed}}
 
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[[Image:1zp8.png|left|200px]]
 
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==HIV Protease with inhibitor AB-2==
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The line below this paragraph, containing "STRUCTURE_1zp8", creates the "Structure Box" on the page.
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<StructureSection load='1zp8' size='340' side='right'caption='[[1zp8]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZP8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB2:[1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL+(1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE'>AB2</scene></td></tr>
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{{STRUCTURE_1zp8| PDB=1zp8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zp8 OCA], [https://pdbe.org/1zp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zp8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zp8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O92139_9HIV1 O92139_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zp/1zp8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zp8 ConSurf].
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<div style="clear:both"></div>
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===HIV Protease with inhibitor AB-2===
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1ZP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP8 OCA].
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==Reference==
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1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors., Brik A, Alexandratos J, Lin YC, Elder JH, Olson AJ, Wlodawer A, Goodsell DS, Wong CH, Chembiochem. 2005 Jul;6(7):1167-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15934050 15934050]
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Alexandratos, J N.]]
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[[Category: Alexandratos JN]]
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[[Category: Brik, A.]]
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[[Category: Brik A]]
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[[Category: Elder, J H.]]
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[[Category: Elder JH]]
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[[Category: Goodsell, D S.]]
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[[Category: Goodsell DS]]
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[[Category: Olson, A J.]]
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[[Category: Olson AJ]]
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[[Category: Wlodawer, A.]]
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[[Category: Wlodawer A]]
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[[Category: Wong, C H.]]
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[[Category: Wong CH]]
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[[Category: Protease]]
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[[Category: Retroviral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:15:44 2008''
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Current revision

HIV Protease with inhibitor AB-2

PDB ID 1zp8

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