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1s4e

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{{Seed}}
 
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[[Image:1s4e.png|left|200px]]
 
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<!--
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==Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium==
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The line below this paragraph, containing "STRUCTURE_1s4e", creates the "Structure Box" on the page.
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<StructureSection load='1s4e' size='340' side='right'caption='[[1s4e]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s4e]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1s4e| PDB=1s4e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4e OCA], [https://pdbe.org/1s4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4e RCSB], [https://www.ebi.ac.uk/pdbsum/1s4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAL1_PYRFU GAL1_PYRFU] Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Is very specific for its substrate, since it is not able to use D-glucose, D-fructose, D-mannose, 2-deoxy-D-glucose, and D-glucosamine as substrates.<ref>PMID:11978175</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s4e ConSurf].
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<div style="clear:both"></div>
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===Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium===
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==See Also==
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*[[Galactokinase|Galactokinase]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15003454}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15003454 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15003454}}
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==About this Structure==
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1S4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4E OCA].
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==Reference==
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Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase., Hartley A, Glynn SE, Barynin V, Baker PJ, Sedelnikova SE, Verhees C, de Geus D, van der Oost J, Timson DJ, Reece RJ, Rice DW, J Mol Biol. 2004 Mar 19;337(2):387-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15003454 15003454]
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[[Category: Galactokinase]]
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Baker PJ]]
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[[Category: Baker, P J.]]
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[[Category: Barynin V]]
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[[Category: Barynin, V.]]
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[[Category: Glynn SE]]
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[[Category: Geus, D de.]]
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[[Category: Hartley A]]
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[[Category: Glynn, S E.]]
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[[Category: Reece RJ]]
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[[Category: Hartley, A.]]
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[[Category: Rice DW]]
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[[Category: Oost, J van der.]]
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[[Category: Sedelnikova SE]]
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[[Category: Reece, R J.]]
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[[Category: Timson DJ]]
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[[Category: Rice, D W.]]
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[[Category: Verhees C]]
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[[Category: Sedelnikova, S E.]]
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[[Category: De Geus D]]
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[[Category: Timson, D J.]]
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[[Category: Van der Oost J]]
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[[Category: Verhees, C.]]
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[[Category: Ghmp kinase superfamily]]
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[[Category: P-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:22:08 2008''
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Current revision

Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium

PDB ID 1s4e

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