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1tk1

From Proteopedia

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{{Seed}}
 
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[[Image:1tk1.png|left|200px]]
 
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<!--
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==YEAST OXYGEN-DEPENDENT COPROPORPHYRINOGEN OXIDASE==
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The line below this paragraph, containing "STRUCTURE_1tk1", creates the "Structure Box" on the page.
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<StructureSection load='1tk1' size='340' side='right'caption='[[1tk1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tk1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TK1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk1 OCA], [https://pdbe.org/1tk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tk1 RCSB], [https://www.ebi.ac.uk/pdbsum/1tk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk1 ProSAT]</span></td></tr>
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{{STRUCTURE_1tk1| PDB=1tk1 | SCENE= }}
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</table>
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== Function ==
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===YEAST OXYGEN-DEPENDENT COPROPORPHYRINOGEN OXIDASE===
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[https://www.uniprot.org/uniprot/HEM6_YEAST HEM6_YEAST] Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15194705}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15194705 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tk1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15194705}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tk1 ConSurf].
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1TK1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK1 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae., Phillips JD, Whitby FG, Warby CA, Labbe P, Yang C, Pflugrath JW, Ferrara JD, Robinson H, Kushner JP, Hill CP, J Biol Chem. 2004 Sep 10;279(37):38960-8. Epub 2004 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15194705 15194705]
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[[Category: Large Structures]]
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[[Category: Coproporphyrinogen oxidase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Ferrara JD]]
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[[Category: Ferrara, J D.]]
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[[Category: Hill CP]]
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[[Category: Hill, C P.]]
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[[Category: Kushner JP]]
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[[Category: Kushner, J P.]]
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[[Category: Labbe P]]
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[[Category: Labbe, P.]]
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[[Category: Pflugrath JW]]
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[[Category: Pflugrath, J W.]]
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[[Category: Phillips JD]]
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[[Category: Phillips, J D.]]
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[[Category: Robinson H]]
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[[Category: Robinson, H.]]
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[[Category: Warby CA]]
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[[Category: Warby, C A.]]
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[[Category: Whitby FG]]
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[[Category: Whitby, F G.]]
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[[Category: Yang C]]
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[[Category: Yang, C.]]
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[[Category: Coproporphyrinogen oxidase]]
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[[Category: Enzyme]]
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[[Category: Heme biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:23:55 2008''
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Current revision

YEAST OXYGEN-DEPENDENT COPROPORPHYRINOGEN OXIDASE

PDB ID 1tk1

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