1u2z

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{{Seed}}
 
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[[Image:1u2z.png|left|200px]]
 
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==Crystal structure of histone K79 methyltransferase Dot1p from yeast==
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The line below this paragraph, containing "STRUCTURE_1u2z", creates the "Structure Box" on the page.
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<StructureSection load='1u2z' size='340' side='right'caption='[[1u2z]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u2z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U2Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_1u2z| PDB=1u2z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u2z OCA], [https://pdbe.org/1u2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u2z RCSB], [https://www.ebi.ac.uk/pdbsum/1u2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u2z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1_YEAST DOT1_YEAST] Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).<ref>PMID:9755194</ref> <ref>PMID:11029058</ref> <ref>PMID:12097318</ref> <ref>PMID:12152067</ref> <ref>PMID:12574507</ref> <ref>PMID:15632126</ref> <ref>PMID:16166626</ref> <ref>PMID:15292170</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u2/1u2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u2z ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of histone K79 methyltransferase Dot1p from yeast===
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15292170}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15292170 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15292170}}
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==About this Structure==
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1U2Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2Z OCA].
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==Reference==
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Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase., Sawada K, Yang Z, Horton JR, Collins RE, Zhang X, Cheng X, J Biol Chem. 2004 Oct 8;279(41):43296-306. Epub 2004 Jul 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15292170 15292170]
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Cheng X]]
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[[Category: Cheng, X.]]
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[[Category: Collins RE]]
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[[Category: Collins, R E.]]
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[[Category: Horton JR]]
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[[Category: Horton, J R.]]
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[[Category: Sawada K]]
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[[Category: Sawada, K.]]
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[[Category: Yang Z]]
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[[Category: Yang, Z.]]
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[[Category: Zhang X]]
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[[Category: Zhang, X.]]
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[[Category: Histone methyltransferase]]
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[[Category: Nucleosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:28:28 2008''
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Current revision

Crystal structure of histone K79 methyltransferase Dot1p from yeast

PDB ID 1u2z

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