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1qc5

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{{Seed}}
 
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[[Image:1qc5.png|left|200px]]
 
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<!--
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==I Domain from Integrin Alpha1-Beta1==
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The line below this paragraph, containing "STRUCTURE_1qc5", creates the "Structure Box" on the page.
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<StructureSection load='1qc5' size='340' side='right'caption='[[1qc5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QC5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1qc5| PDB=1qc5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qc5 OCA], [https://pdbe.org/1qc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qc5 RCSB], [https://www.ebi.ac.uk/pdbsum/1qc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qc5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITA1_HUMAN ITA1_HUMAN] Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/1qc5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qc5 ConSurf].
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<div style="clear:both"></div>
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===I DOMAIN FROM INTEGRIN ALPHA1-BETA1===
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==See Also==
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*[[Integrin 3D structures|Integrin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10455165}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10455165 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10455165}}
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==About this Structure==
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1QC5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QC5 OCA].
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==Reference==
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Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM., Rich RL, Deivanayagam CC, Owens RT, Carson M, Hook A, Moore D, Symersky J, Yang VW, Narayana SV, Hook M, J Biol Chem. 1999 Aug 27;274(35):24906-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10455165 10455165]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Deivanayagam, C C.]]
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[[Category: Deivanayagam CC]]
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[[Category: Narayana, S V.]]
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[[Category: Narayana SV]]
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[[Category: Cell adhesion]]
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[[Category: Integrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:31:09 2008''
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Current revision

I Domain from Integrin Alpha1-Beta1

PDB ID 1qc5

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