2gtt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:13, 18 October 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2gtt.png|left|200px]]
 
-
<!--
+
==Crystal structure of the rabies virus nucleoprotein-RNA complex==
-
The line below this paragraph, containing "STRUCTURE_2gtt", creates the "Structure Box" on the page.
+
<StructureSection load='2gtt' size='340' side='right'caption='[[2gtt]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTT FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.49&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtt OCA], [https://pdbe.org/2gtt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gtt RCSB], [https://www.ebi.ac.uk/pdbsum/2gtt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gtt ProSAT]</span></td></tr>
-
{{STRUCTURE_2gtt| PDB=2gtt | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NCAP_RABVE NCAP_RABVE] Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid formation. The two core domains of the nucleoprotein clamp around the RNA at their interface and shield it from the environment. RNA sequestering by nucleoproteins is likely a common mechanism used by negative-strand RNA viruses to protect their genomes from the innate immune response directed against viral RNA in human host cells at certain stages of an infectious cycle.
-
===Crystal structure of the rabies virus nucleoprotein-RNA complex===
+
Crystal structure of the rabies virus nucleoprotein-RNA complex.,Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, Schoehn G, Weissenhorn W, Ruigrok RW Science. 2006 Jul 21;313(5785):360-3. Epub 2006 Jun 15. PMID:16778023<ref>PMID:16778023</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2gtt" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16778023}}, adds the Publication Abstract to the page
+
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16778023 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16778023}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2GTT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA].
+
[[Category: Rabies lyssavirus]]
-
 
+
[[Category: Albertini AAV]]
-
==Reference==
+
[[Category: Muziol T]]
-
Crystal structure of the rabies virus nucleoprotein-RNA complex., Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, Schoehn G, Weissenhorn W, Ruigrok RW, Science. 2006 Jul 21;313(5785):360-3. Epub 2006 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16778023 16778023]
+
[[Category: Ravelli RBG]]
-
[[Category: Rabies virus]]
+
[[Category: Ruigrok RWH]]
-
[[Category: Single protein]]
+
[[Category: Weissenhorn W]]
-
[[Category: Albertini, A A.V.]]
+
[[Category: Wernimont AK]]
-
[[Category: Muziol, T.]]
+
-
[[Category: Ravelli, R B.G.]]
+
-
[[Category: Ruigrok, R W.H.]]
+
-
[[Category: Weissenhorn, W.]]
+
-
[[Category: Wernimont, A K.]]
+
-
[[Category: Nucleoprotein]]
+
-
[[Category: Protein-rna complex]]
+
-
[[Category: Rabies virus]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:33:47 2008''
+

Current revision

Crystal structure of the rabies virus nucleoprotein-RNA complex

PDB ID 2gtt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gtt"
Personal tools