2icj

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{{Seed}}
 
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[[Image:2icj.png|left|200px]]
 
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==The crystal structure of human isopentenyl diphophate isomerase==
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The line below this paragraph, containing "STRUCTURE_2icj", creates the "Structure Box" on the page.
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<StructureSection load='2icj' size='340' side='right'caption='[[2icj]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2icj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ICJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2icj| PDB=2icj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2icj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icj OCA], [https://pdbe.org/2icj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2icj RCSB], [https://www.ebi.ac.uk/pdbsum/2icj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2icj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDI1_HUMAN IDI1_HUMAN] Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).<ref>PMID:8806705</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/2icj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2icj ConSurf].
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<div style="clear:both"></div>
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===The crystal structure of human isopentenyl diphophate isomerase===
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==See Also==
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*[[Isopentenyl-diphosphate delta-isomerase|Isopentenyl-diphosphate delta-isomerase]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17250851 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17250851}}
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==About this Structure==
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2ICJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICJ OCA].
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==Reference==
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The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis., Zheng W, Sun F, Bartlam M, Li X, Li R, Rao Z, J Mol Biol. 2007 Mar 9;366(5):1447-58. Epub 2006 Dec 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17250851 17250851]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Isopentenyl-diphosphate Delta-isomerase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Bartlam M]]
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[[Category: Bartlam, M.]]
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[[Category: Rao Z]]
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[[Category: Rao, Z.]]
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[[Category: Zheng W]]
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[[Category: Zheng, W.]]
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[[Category: Crystal structure]]
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[[Category: Human isopentenyl diphophate isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:35:22 2008''
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Current revision

The crystal structure of human isopentenyl diphophate isomerase

PDB ID 2icj

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