1y2a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:54, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1y2a.png|left|200px]]
 
-
<!--
+
==Structure of mammalian importin bound to the non-classical PLSCR1-NLS==
-
The line below this paragraph, containing "STRUCTURE_1y2a", creates the "Structure Box" on the page.
+
<StructureSection load='1y2a' size='340' side='right'caption='[[1y2a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1y2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y2A FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2a OCA], [https://pdbe.org/1y2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y2a RCSB], [https://www.ebi.ac.uk/pdbsum/1y2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y2a ProSAT]</span></td></tr>
-
{{STRUCTURE_1y2a| PDB=1y2a | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y2/1y2a_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y2a ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of mammalian importin bound to the non-classical PLSCR1-NLS===
+
==See Also==
-
 
+
*[[Importin 3D structures|Importin 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15611084}}, adds the Publication Abstract to the page
+
[[Category: Homo sapiens]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 15611084 is the PubMed ID number.
+
[[Category: Large Structures]]
-
-->
+
-
{{ABSTRACT_PUBMED_15611084}}
+
-
 
+
-
==About this Structure==
+
-
1Y2A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2A OCA].
+
-
 
+
-
==Reference==
+
-
Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha., Chen MH, Ben-Efraim I, Mitrousis G, Walker-Kopp N, Sims PJ, Cingolani G, J Biol Chem. 2005 Mar 18;280(11):10599-606. Epub 2004 Dec 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15611084 15611084]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Protein complex]]
+
[[Category: Ben-Efraim I]]
-
[[Category: Ben-Efraim, I.]]
+
[[Category: Chen M-H]]
-
[[Category: Chen, M H.]]
+
[[Category: Cingolani G]]
-
[[Category: Cingolani, G.]]
+
[[Category: Mitrousis G]]
-
[[Category: Mitrousis, G.]]
+
[[Category: Sims PJ]]
-
[[Category: Sims, P J.]]
+
[[Category: Walker-Kopp N]]
-
[[Category: Walker-Kopp, N.]]
+
-
[[Category: Armadillo repeat]]
+
-
[[Category: Protein:peptide complex]]
+
-
[[Category: Superhelix of helice]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:51:05 2008''
+

Current revision

Structure of mammalian importin bound to the non-classical PLSCR1-NLS

PDB ID 1y2a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1y2a"
Personal tools