1x5v

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{{Seed}}
 
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[[Image:1x5v.png|left|200px]]
 
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==NMR Structure of PcFK1==
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The line below this paragraph, containing "STRUCTURE_1x5v", creates the "Structure Box" on the page.
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<StructureSection load='1x5v' size='340' side='right'caption='[[1x5v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x5v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Psalmopoeus_cambridgei Psalmopoeus cambridgei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HSL:HOMOSERINE+LACTONE'>HSL</scene></td></tr>
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{{STRUCTURE_1x5v| PDB=1x5v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5v OCA], [https://pdbe.org/1x5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5v RCSB], [https://www.ebi.ac.uk/pdbsum/1x5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NTA_PSACA NTA_PSACA] Possesses strong antiplasmodial activity against the intra-erythrocyte stage of P.falciparum in vitro. IC(50) for inhibiting P.falciparum growth is 1.59 uM. Interacts with infected and healthy erythrocytes. Does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. Has neither antibacterial nor antifungal activity.<ref>PMID:15304333</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Psalmopeotoxin I (PcFK1) is a 33-amino-acid residue peptide isolated from the venom of the tarantula Psalmopoeus cambridgei. It has been recently shown to possess strong antiplasmodial activity against the intra-erythrocyte stage of Plasmodium falciparum in vitro. Although the molecular target for PcFK1 is not yet determined, this peptide does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. We investigated the structural properties of PcFK1 to help understand the unique mechanism of action of this peptide and to enhance its utility as a lead compound for rational development of new antimalarial drugs. In this paper, we have determined the three-dimensional solution structure by (1)H two-dimensional NMR means of recombinant PcFK1, which is shown to belong to the ICK structural superfamily with structural determinants common to several neurotoxins acting as ion channels effectors.
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===NMR Structure of PcFK1===
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Solution structure of PcFK1, a spider peptide active against Plasmodium falciparum.,Pimentel C, Choi SJ, Chagot B, Guette C, Camadro JM, Darbon H Protein Sci. 2006 Mar;15(3):628-34. Epub 2006 Feb 1. PMID:16452619<ref>PMID:16452619</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16452619}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1x5v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16452619 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16452619}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].
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[[Category: Psalmopoeus cambridgei]]
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[[Category: Camadro JM]]
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==Reference==
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[[Category: Chagot B]]
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Solution structure of PcFK1, a spider peptide active against Plasmodium falciparum., Pimentel C, Choi SJ, Chagot B, Guette C, Camadro JM, Darbon H, Protein Sci. 2006 Mar;15(3):628-34. Epub 2006 Feb 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16452619 16452619]
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[[Category: Choi SJ]]
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[[Category: Camadro, J M.]]
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[[Category: Darbon H]]
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[[Category: Chagot, B.]]
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[[Category: Guette C]]
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[[Category: Choi, S J.]]
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[[Category: Pimentel C]]
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[[Category: Darbon, H.]]
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[[Category: Guette, C.]]
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[[Category: Pimentel, C.]]
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[[Category: Inhibitory cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:51:59 2008''
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Current revision

NMR Structure of PcFK1

PDB ID 1x5v

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