2ex3

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{{Seed}}
 
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[[Image:2ex3.png|left|200px]]
 
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==Bacteriophage phi29 DNA polymerase bound to terminal protein==
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The line below this paragraph, containing "STRUCTURE_2ex3", creates the "Structure Box" on the page.
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<StructureSection load='2ex3' size='340' side='right'caption='[[2ex3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ex3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_phi29 Bacillus virus phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EX3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
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{{STRUCTURE_2ex3| PDB=2ex3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ex3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex3 OCA], [https://pdbe.org/2ex3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ex3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ex3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOL_BPPH2 DPOL_BPPH2] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ex3 ConSurf].
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<div style="clear:both"></div>
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===Bacteriophage phi29 DNA polymerase bound to terminal protein===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16511564}}, adds the Publication Abstract to the page
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[[Category: Bacillus virus phi29]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16511564 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Berman AJ]]
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{{ABSTRACT_PUBMED_16511564}}
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[[Category: Blanco L]]
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[[Category: Kamtekar S]]
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==About this Structure==
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[[Category: Salas M]]
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2EX3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX3 OCA].
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[[Category: Steitz TA]]
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[[Category: Wang J]]
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==Reference==
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[[Category: De Vega M]]
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The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition., Kamtekar S, Berman AJ, Wang J, Lazaro JM, de Vega M, Blanco L, Salas M, Steitz TA, EMBO J. 2006 Mar 22;25(6):1335-43. Epub 2006 Mar 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511564 16511564]
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[[Category: Bacillus phage phi29]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Protein complex]]
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[[Category: Berman, A J.]]
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[[Category: Blanco, L.]]
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[[Category: Kamtekar, S.]]
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[[Category: Salas, M.]]
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[[Category: Steitz, T A.]]
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[[Category: Vega, M de.]]
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[[Category: Wang, J.]]
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[[Category: Dna polymerase: protein primer complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:57:13 2008''
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Current revision

Bacteriophage phi29 DNA polymerase bound to terminal protein

PDB ID 2ex3

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OCA

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