2b07

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{{Seed}}
 
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[[Image:2b07.png|left|200px]]
 
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==Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.==
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The line below this paragraph, containing "STRUCTURE_2b07", creates the "Structure Box" on the page.
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<StructureSection load='2b07' size='340' side='right'caption='[[2b07]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B07 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=598:6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>598</scene></td></tr>
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{{STRUCTURE_2b07| PDB=2b07 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b07 OCA], [https://pdbe.org/2b07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b07 RCSB], [https://www.ebi.ac.uk/pdbsum/2b07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b07 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b07_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b07 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.===
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16303309 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16303309}}
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==About this Structure==
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2B07 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B07 OCA].
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==Reference==
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Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16303309 16303309]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Binnun E]]
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[[Category: Binnun, E.]]
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[[Category: Erbe DV]]
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[[Category: Erbe, D V.]]
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[[Category: Follows BC]]
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[[Category: Follows, B C.]]
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[[Category: Foreman K]]
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[[Category: Foreman, K.]]
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[[Category: Joseph-McCarthy D]]
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[[Category: Joseph-McCarthy, D.]]
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[[Category: Kirincich SJ]]
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[[Category: Kirincich, S J.]]
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[[Category: Lee J]]
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[[Category: Lee, J.]]
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[[Category: Moretto AF]]
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[[Category: Moretto, A F.]]
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[[Category: Smith MJ]]
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[[Category: Smith, M J.]]
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[[Category: Tam SK]]
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[[Category: Tam, S K.]]
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[[Category: Tam SY]]
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[[Category: Tam, S Y.]]
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[[Category: Wan ZK]]
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[[Category: Wan, Z K.]]
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[[Category: Wilson DP]]
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[[Category: Wilson, D P.]]
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[[Category: Xu WX]]
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[[Category: Xu, W X.]]
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[[Category: Zhang YL]]
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[[Category: Zhang, Y L.]]
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[[Category: Hydrolyase]]
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[[Category: Protein tyrosine phosphatase]]
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[[Category: Tricyclic thiophene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:59:47 2008''
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Current revision

Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.

PDB ID 2b07

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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