2z8z

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{{Seed}}
 
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[[Image:2z8z.png|left|200px]]
 
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==Crystal structure of a platinum-bound S445C mutant of Pseudomonas sp. MIS38 lipase==
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The line below this paragraph, containing "STRUCTURE_2z8z", creates the "Structure Box" on the page.
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<StructureSection load='2z8z' size='340' side='right'caption='[[2z8z]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z8z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._MIS38 Pseudomonas sp. MIS38]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2z8z| PDB=2z8z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8z OCA], [https://pdbe.org/2z8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8z RCSB], [https://www.ebi.ac.uk/pdbsum/2z8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9RBY1_9PSED Q9RBY1_9PSED]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/2z8z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z8z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation was determined at 1.5A resolution. This structure highly resembles that of Serratia marcescens LipA in an open conformation, except for the structures of two lids. Lid1 is anchored by a Ca2+ ion (Ca1) in an open conformation, but lacks this Ca1 site and greatly changes its structure and position in a closed conformation. Lid2 forms a helical hairpin in an open conformation, but does not form it and covers the active site in a closed conformation. Based on these results, we discuss on the lid-opening mechanism.
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===Crystal structure of a platinum-bound S445C mutant of Pseudomonas sp. MIS38 lipase===
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Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation.,Angkawidjaja C, You DJ, Matsumura H, Kuwahara K, Koga Y, Takano K, Kanaya S FEBS Lett. 2007 Oct 30;581(26):5060-4. Epub 2007 Oct 1. PMID:17923123<ref>PMID:17923123</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2z8z" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17923123}}, adds the Publication Abstract to the page
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*[[Lipase 3D Structures|Lipase 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17923123 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17923123}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2Z8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._mis38 Pseudomonas sp. mis38]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8Z OCA].
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[[Category: Pseudomonas sp. MIS38]]
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[[Category: Angkawidjaja C]]
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==Reference==
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[[Category: Kanaya S]]
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Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation., Angkawidjaja C, You DJ, Matsumura H, Kuwahara K, Koga Y, Takano K, Kanaya S, FEBS Lett. 2007 Oct 30;581(26):5060-4. Epub 2007 Oct 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17923123 17923123]
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[[Category: Koga Y]]
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[[Category: Pseudomonas sp. mis38]]
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[[Category: Matsumura H]]
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[[Category: Single protein]]
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[[Category: Takano K]]
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[[Category: Triacylglycerol lipase]]
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[[Category: You DJ]]
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[[Category: Angkawidjaja, C.]]
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[[Category: Kanaya, S.]]
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[[Category: Koga, Y.]]
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[[Category: Matsumura, H.]]
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[[Category: Takano, K.]]
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[[Category: You, D J.]]
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[[Category: Beta-roll]]
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[[Category: Calcium-binding protein]]
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[[Category: Family i 3 lipase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:04:33 2008''
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Current revision

Crystal structure of a platinum-bound S445C mutant of Pseudomonas sp. MIS38 lipase

PDB ID 2z8z

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