2np2

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{{Seed}}
 
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[[Image:2np2.png|left|200px]]
 
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==Hbb-DNA complex==
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The line below this paragraph, containing "STRUCTURE_2np2", creates the "Structure Box" on the page.
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<StructureSection load='2np2' size='340' side='right'caption='[[2np2]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2np2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NP2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2np2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2np2 OCA], [https://pdbe.org/2np2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2np2 RCSB], [https://www.ebi.ac.uk/pdbsum/2np2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2np2 ProSAT]</span></td></tr>
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{{STRUCTURE_2np2| PDB=2np2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DBH_BORBU DBH_BORBU] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/2np2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2np2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The genome of the Lyme disease-causing spirochete Borrelia burgdorferi encodes only a single polypeptide from the integration host factor (IHF)/HU or 'DNABII' family of nucleoid-associated proteins - Hbb. DNABII proteins induce large bends in DNA and serve as architectural factors in a variety of prokaryotic cellular processes. We have solved the crystal structure of an Hbb-DNA complex in which the DNA is bent by over 180 degrees . We find that like IHF, Hbb relies exclusively on indirect readout to recognize its cognate site. Additional binding studies show that the sequence preferences of Hbb are related to, yet distinct from those of IHF. Defining these binding characteristics may help to uncover additional roles for Hbb in Borrelia DNA metabolism as well as further our understanding of the mechanism of indirect readout.
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===Hbb-DNA complex===
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Shaping the Borrelia burgdorferi genome: crystal structure and binding properties of the DNA-bending protein Hbb.,Mouw KW, Rice PA Mol Microbiol. 2007 Mar;63(5):1319-30. Epub 2007 Jan 22. PMID:17244195<ref>PMID:17244195</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17244195}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2np2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17244195 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17244195}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Borreliella burgdorferi]]
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2NP2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NP2 OCA].
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[[Category: Large Structures]]
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[[Category: Mouw KW]]
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==Reference==
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[[Category: Rice PA]]
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Shaping the Borrelia burgdorferi genome: crystal structure and binding properties of the DNA-bending protein Hbb., Mouw KW, Rice PA, Mol Microbiol. 2007 Mar;63(5):1319-30. Epub 2007 Jan 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17244195 17244195]
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[[Category: Borrelia burgdorferi]]
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[[Category: Single protein]]
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[[Category: Mouw, K W.]]
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[[Category: Rice, P A.]]
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[[Category: Dna-bending protein]]
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[[Category: Dna-binding protein]]
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[[Category: Dnabii family]]
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[[Category: Hu/ihf family]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:24:22 2008''
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Current revision

Hbb-DNA complex

PDB ID 2np2

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OCA

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