2i68

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{{Seed}}
 
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[[Image:2i68.png|left|200px]]
 
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==Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance antiporter from E. coli EmrE==
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The line below this paragraph, containing "STRUCTURE_2i68", creates the "Structure Box" on the page.
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<StructureSection load='2i68' size='340' side='right'caption='[[2i68]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I68 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 7.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i68 OCA], [https://pdbe.org/2i68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i68 RCSB], [https://www.ebi.ac.uk/pdbsum/2i68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i68 ProSAT]</span></td></tr>
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{{STRUCTURE_2i68| PDB=2i68 | SCENE= }}
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</table>
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== Function ==
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===Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance antiporter from E. coli EmrE===
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[https://www.uniprot.org/uniprot/EMRE_ECOLI EMRE_ECOLI] Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium.<ref>PMID:7896833</ref> <ref>PMID:10681497</ref> <ref>PMID:15371426</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17005200 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i68_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17005200}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i68 ConSurf].
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2I68 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I68 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Quasi-symmetry in the cryo-EM structure of EmrE provides the key to modeling its transmembrane domain., Fleishman SJ, Harrington SE, Enosh A, Halperin D, Tate CG, Ben-Tal N, J Mol Biol. 2006 Nov 17;364(1):54-67. Epub 2006 Aug 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17005200 17005200]
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__TOC__
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</StructureSection>
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Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer., Ubarretxena-Belandia I, Baldwin JM, Schuldiner S, Tate CG, EMBO J. 2003 Dec 1;22(23):6175-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14633977 14633977]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ben-Tal, N.]]
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[[Category: Ben-Tal N]]
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[[Category: Enosh, A.]]
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[[Category: Enosh A]]
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[[Category: Fleishman, S J.]]
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[[Category: Fleishman SJ]]
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[[Category: Halperin, D.]]
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[[Category: Halperin D]]
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[[Category: Harrington, S E.]]
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[[Category: Harrington SE]]
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[[Category: Tate, C G.]]
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[[Category: Tate CG]]
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[[Category: Dual topology]]
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[[Category: Homodimer]]
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[[Category: Small-multidrug resistance]]
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[[Category: Transmembrane protein]]
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[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:28:30 2008''
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Current revision

Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance antiporter from E. coli EmrE

PDB ID 2i68

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