1xoz

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{{Seed}}
 
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[[Image:1xoz.png|left|200px]]
 
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==Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil==
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The line below this paragraph, containing "STRUCTURE_1xoz", creates the "Structure Box" on the page.
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<StructureSection load='1xoz' size='340' side='right'caption='[[1xoz]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xoz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XOZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1xoz| PDB=1xoz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xoz OCA], [https://pdbe.org/1xoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xoz RCSB], [https://www.ebi.ac.uk/pdbsum/1xoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xoz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xo/1xoz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xoz ConSurf].
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<div style="clear:both"></div>
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===Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15576036}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15576036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15576036}}
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==About this Structure==
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1XOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOZ OCA].
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==Reference==
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Structural basis for the activity of drugs that inhibit phosphodiesterases., Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY, Structure. 2004 Dec;12(12):2233-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576036 15576036]
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Artis, D R.]]
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[[Category: Artis DR]]
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[[Category: Bollag, G.]]
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[[Category: Bollag G]]
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[[Category: Card, G L.]]
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[[Category: Card GL]]
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[[Category: England, B P.]]
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[[Category: England BP]]
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[[Category: Fong, D.]]
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[[Category: Fong D]]
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[[Category: Gillette, S.]]
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[[Category: Gillette S]]
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[[Category: Ibrahim, P N.]]
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[[Category: Ibrahim PN]]
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[[Category: Kim, S H.]]
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[[Category: Kim S-H]]
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[[Category: Lee, B.]]
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[[Category: Lee B]]
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[[Category: Luu, C.]]
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[[Category: Luu C]]
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[[Category: Milburn, M V.]]
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[[Category: Milburn MV]]
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[[Category: Powell, B.]]
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[[Category: Powell B]]
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[[Category: Schlessinger, J.]]
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[[Category: Schlessinger J]]
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[[Category: Suzuki, Y.]]
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[[Category: Suzuki Y]]
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[[Category: Tabrizizad, M.]]
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[[Category: Tabrizizad M]]
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[[Category: Zhang, K Y.J.]]
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[[Category: Zhang KYJ]]
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[[Category: Ciali]]
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[[Category: Pde]]
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[[Category: Pde5a]]
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[[Category: Phosphodiesterase]]
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[[Category: Tadalafil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:36:00 2008''
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Current revision

Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil

PDB ID 1xoz

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