1ukk

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{{Seed}}
 
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[[Image:1ukk.png|left|200px]]
 
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==Structure of Osmotically Inducible Protein C from Thermus thermophilus==
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The line below this paragraph, containing "STRUCTURE_1ukk", creates the "Structure Box" on the page.
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<StructureSection load='1ukk' size='340' side='right'caption='[[1ukk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ukk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UKK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_1ukk| PDB=1ukk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ukk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ukk OCA], [https://pdbe.org/1ukk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ukk RCSB], [https://www.ebi.ac.uk/pdbsum/1ukk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ukk ProSAT], [https://www.topsan.org/Proteins/RSGI/1ukk TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P84124_THETH P84124_THETH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uk/1ukk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ukk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray crystallographic structure of osmotically inducible Protein C from the thermophilic bacterium, Thermus thermophilus HB8, was solved to 1.6A using the multiple wavelength anomalous dispersion method and a selenomethionine incorporated protein (Se-MAD). The crystal space group was P1 with cell dimensions of a=37.58 A, b=40.95 A, c=48.14 A, alpha=76.9 degrees, beta=74.0 degrees and gamma=64.1 degrees. The two tightly interacting monomers in the asymmetric unit are related by a non-crystallographic 2-fold. The dimer structure is defined primarily by two very long anti-parallel, over-lapping alpha-helices at the core, with a further six-stranded anti-parallel beta-sheet on the outside of the structure. With respect to the beta-sheets, both A and B monomers contribute three strands each resulting in an intertwining of the structure. The active site consists of two cysteine residues from one monomer and an arginine and glutamic acid from the other. Enzymatic assays have revealed that T.thermophilus OsmC has a hydroperoxide peroxidase activity.
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===Structure of Osmotically Inducible Protein C from Thermus thermophilus===
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Crystallographic structure and biochemical analysis of the Thermus thermophilus osmotically inducible protein C.,Rehse PH, Ohshima N, Nodake Y, Tahirov TH J Mol Biol. 2004 May 14;338(5):959-68. PMID:15111059<ref>PMID:15111059</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15111059}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ukk" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15111059 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15111059}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1UKK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKK OCA].
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[[Category: Thermus thermophilus HB8]]
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[[Category: Kuramitsu S]]
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==Reference==
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[[Category: Miyano M]]
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Crystallographic structure and biochemical analysis of the Thermus thermophilus osmotically inducible protein C., Rehse PH, Ohshima N, Nodake Y, Tahirov TH, J Mol Biol. 2004 May 14;338(5):959-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15111059 15111059]
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[[Category: Rehse PH]]
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[[Category: Single protein]]
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[[Category: Tahirov TH]]
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[[Category: Thermus thermophilus]]
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[[Category: Yokoyama S]]
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[[Category: Kuramitsu, S.]]
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[[Category: Miyano, M.]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Rehse, P H.]]
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[[Category: Tahirov, T H.]]
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[[Category: Yokoyama, S.]]
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[[Category: Cysteinesulfinic acid]]
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[[Category: Inducible]]
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[[Category: Osmotic]]
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[[Category: Peroxidase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:39:54 2008''
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Current revision

Structure of Osmotically Inducible Protein C from Thermus thermophilus

PDB ID 1ukk

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