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1q8a

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{{Seed}}
 
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[[Image:1q8a.png|left|200px]]
 
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==Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+:L-Hcy complex, Se-Met)==
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The line below this paragraph, containing "STRUCTURE_1q8a", creates the "Structure Box" on the page.
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<StructureSection load='1q8a' size='340' side='right'caption='[[1q8a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1q8a| PDB=1q8a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8a OCA], [https://pdbe.org/1q8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8a RCSB], [https://www.ebi.ac.uk/pdbsum/1q8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WYA5_THEMA Q9WYA5_THEMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8a ConSurf].
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<div style="clear:both"></div>
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===Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+:L-Hcy complex, Se-Met)===
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==See Also==
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*[[Methionine synthase 3D structures|Methionine synthase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14752199}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14752199 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14752199}}
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==About this Structure==
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1Q8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8A OCA].
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==Reference==
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Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase., Evans JC, Huddler DP, Hilgers MT, Romanchuk G, Matthews RG, Ludwig ML, Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3729-36. Epub 2004 Jan 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14752199 14752199]
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[[Category: Methionine synthase]]
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[[Category: Single protein]]
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Evans, J C.]]
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[[Category: Evans JC]]
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[[Category: Hilgers, M T.]]
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[[Category: Hilgers MT]]
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[[Category: Huddler, D P.]]
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[[Category: Huddler DP]]
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[[Category: Ludwig, M L.]]
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[[Category: Ludwig ML]]
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[[Category: Matthews, R G.]]
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[[Category: Matthews RG]]
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[[Category: Romanchuk, G.]]
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[[Category: Romanchuk G]]
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[[Category: Cobalamin]]
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[[Category: Folate]]
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[[Category: Homocysteine]]
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[[Category: Methionine]]
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[[Category: Vitamin b12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:52:17 2008''
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Current revision

Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+:L-Hcy complex, Se-Met)

PDB ID 1q8a

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