1r1b

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{{Seed}}
 
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[[Image:1r1b.png|left|200px]]
 
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==EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1r1b", creates the "Structure Box" on the page.
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<StructureSection load='1r1b' size='340' side='right'caption='[[1r1b]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1b OCA], [https://pdbe.org/1r1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1b RCSB], [https://www.ebi.ac.uk/pdbsum/1r1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1b ProSAT]</span></td></tr>
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{{STRUCTURE_1r1b| PDB=1r1b | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYEP_CRIGR SYEP_CRIGR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r1b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these repeated motifs was also solved by NMR spectroscopy. One repeat is built around an antiparallel coiled-coil. Strikingly, the conserved lysine and arginine residues form a basic patch on one side of the structure, presenting a suitable docking surface for nucleic acids. Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor.
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===EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE===
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A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.,Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942<ref>PMID:10654942</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10654942}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1r1b" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10654942 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10654942}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1R1B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA].
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==Reference==
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A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases., Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M, EMBO J. 2000 Feb 1;19(3):445-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10654942 10654942]
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[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Berthonneau, E.]]
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[[Category: Berthonneau E]]
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[[Category: Birlirakis, N.]]
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[[Category: Birlirakis N]]
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[[Category: Cahuzac, B.]]
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[[Category: Cahuzac B]]
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[[Category: Guittet, E.]]
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[[Category: Guittet E]]
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[[Category: Mirande, M.]]
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[[Category: Mirande M]]
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[[Category: Protein transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:07:39 2008''
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Current revision

EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1r1b

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