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2j6o

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ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER

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Retrieved from "http://52.214.119.220/wiki/index.php/2j6o"

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2j6o.png|left|200px]]
-<!--
+==ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER==
-The line below this paragraph, containing "STRUCTURE_2j6o", creates the "Structure Box" on the page.
+<StructureSection load='2j6o' size='340' side='right'caption='[[2j6o]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2j6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J6O FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6o OCA], [https://pdbe.org/2j6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j6o RCSB], [https://www.ebi.ac.uk/pdbsum/2j6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j6o ProSAT]</span></td></tr>
-{{STRUCTURE_2j6o|  PDB=2j6o  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[https://omim.org/entry/607832 607832]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN] Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.<ref>PMID:15800069</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j6o_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j6o ConSurf].
+<div style="clear:both"></div>
-===ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER===
+==See Also==
+*[[CD2-associated protein|CD2-associated protein]]
+*[[CD2-associated protein 3D structures|CD2-associated protein 3D structures]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_17020880}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 17020880 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_17020880}}
-==About this Structure==
-J6O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6O OCA].
-==Reference==
-Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17020880 17020880]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Bravo, J.]]
+[[Category: Bravo J]]
-[[Category: Cardenes, N.]]
+[[Category: Cardenes N]]
-[[Category: Deribe, Y L.]]
+[[Category: Deribe YL]]
-[[Category: Dikic, I.]]
+[[Category: Dikic I]]
-[[Category: Moncalian, G.]]
+[[Category: Moncalian G]]
-[[Category: Spinola-Amilibia, M.]]
+[[Category: Spinola-Amilibia M]]
-[[Category: Adaptor protein]]
-[[Category: Cm]]
-[[Category: Coiled coil]]
-[[Category: Egfr downregulation]]
-[[Category: Phosphorylation]]
-[[Category: Protein binding]]
-[[Category: Sh3 domain]]
-[[Category: Sh3 domain recognition]]
-[[Category: Sh3-binding]]
-[[Category: Signaling protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:08:51 2008''

2j6o

From Proteopedia

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ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER

Structural highlights

Disease

Function

Evolutionary Conservation

See Also

References

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