2vl5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:32, 17 October 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2vl5.png|left|200px]]
 
-
<!--
+
==Structure of anti-collagen type II FAb CIIC1==
-
The line below this paragraph, containing "STRUCTURE_2vl5", creates the "Structure Box" on the page.
+
<StructureSection load='2vl5' size='340' side='right'caption='[[2vl5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2vl5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL5 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl5 OCA], [https://pdbe.org/2vl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl5 ProSAT]</span></td></tr>
-
{{STRUCTURE_2vl5| PDB=2vl5 | SCENE= }}
+
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vl5 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment to other anti-collagen antibodies which are of different isotypes and epitope specificity. The rheumatoid factor like reactivity of CIIC1 antibody together with its collagen type II specificity may explain the pathogenicity of this antibody.
-
===STRUCTURE OF ANTI-COLLAGEN TYPE II FAB CIIC1===
+
The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: structure to function analysis.,Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM Mol Immunol. 2008 Apr;45(8):2196-204. Epub 2008 Feb 1. PMID:18241923<ref>PMID:18241923</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2vl5" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_18241923}}, adds the Publication Abstract to the page
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 18241923 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18241923}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2VL5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL5 OCA].
+
-
 
+
-
==Reference==
+
-
The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: Structure to function analysis., Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM, Mol Immunol. 2008 Apr;45(8):2196-204. Epub 2008 Feb 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18241923 18241923]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Boiers U]]
-
[[Category: Boiers, U.]]
+
[[Category: Burkhardt H]]
-
[[Category: Burkhardt, H.]]
+
[[Category: Holmdahl R]]
-
[[Category: Holmdahl, R.]]
+
[[Category: Nandakumar KS]]
-
[[Category: Nandakumar, K S.]]
+
[[Category: Sehnert B]]
-
[[Category: Sehnert, B.]]
+
[[Category: Thunnissen MM]]
-
[[Category: Thunnissen, M M.]]
+
[[Category: Uysal H]]
-
[[Category: Uysal, H.]]
+
-
[[Category: Arthritis]]
+
-
[[Category: Autoantibody]]
+
-
[[Category: Collagen type ii]]
+
-
[[Category: Immune system]]
+
-
[[Category: Rheumatoid factor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:30:07 2008''
+

Current revision

Structure of anti-collagen type II FAb CIIC1

PDB ID 2vl5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vl5"
Personal tools