1xwd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:43, 25 December 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1xwd.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor==
-
The line below this paragraph, containing "STRUCTURE_1xwd", creates the "Structure Box" on the page.
+
<StructureSection load='1xwd' size='340' side='right'caption='[[1xwd]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1xwd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XWD FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1xwd| PDB=1xwd | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwd OCA], [https://pdbe.org/1xwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xwd RCSB], [https://www.ebi.ac.uk/pdbsum/1xwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xwd ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GLHA_HUMAN GLHA_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xwd_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xwd ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human FSH bound to the extracellular hormone-binding domain of its receptor (FSHR(HB)). The hormone is bound in a hand-clasp fashion to an elongated, curved receptor. The buried interface of the complex is large (2,600 A2) and has a high charge density. Our analysis suggests that all glycoprotein hormones bind to their receptors in this mode and that binding specificity is mediated by key interaction sites involving both the common alpha- and hormone-specific beta-subunits. On binding, FSH undergoes a concerted conformational change that affects protruding loops implicated in receptor activation. The FSH-FSHR(HB) complexes form dimers in the crystal and at high concentrations in solution. Such dimers may participate in transmembrane signal transduction.
-
===Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor===
+
Structure of human follicle-stimulating hormone in complex with its receptor.,Fan QR, Hendrickson WA Nature. 2005 Jan 20;433(7023):269-77. PMID:15662415<ref>PMID:15662415</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1xwd" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_15662415}}, adds the Publication Abstract to the page
+
*[[Follicle-stimulating hormone|Follicle-stimulating hormone]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 15662415 is the PubMed ID number.
+
*[[Human Follicle-Stimulating Hormone Complexed with its Receptor|Human Follicle-Stimulating Hormone Complexed with its Receptor]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_15662415}}
+
<references/>
-
 
+
__TOC__
-
==Disease==
+
</StructureSection>
-
Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]]
+
-
 
+
-
==About this Structure==
+
-
1XWD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWD OCA].
+
-
 
+
-
==Reference==
+
-
Structure of human follicle-stimulating hormone in complex with its receptor., Fan QR, Hendrickson WA, Nature. 2005 Jan 20;433(7023):269-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15662415 15662415]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Fan, Q R.]]
+
[[Category: Fan QR]]
-
[[Category: Hendrickson, W A.]]
+
[[Category: Hendrickson WA]]
-
[[Category: Cysteine-knot motif]]
+
-
[[Category: Hormone-receptor complex]]
+
-
[[Category: Leucine-rich repeat]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:42:45 2008''
+

Current revision

Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor

PDB ID 1xwd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xwd"
Personal tools