1nmt

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{{Seed}}
 
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[[Image:1nmt.png|left|200px]]
 
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==N-MYRISTOYL TRANSFERASE FROM CANDIDA ALBICANS AT 2.45 A==
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The line below this paragraph, containing "STRUCTURE_1nmt", creates the "Structure Box" on the page.
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<StructureSection load='1nmt' size='340' side='right'caption='[[1nmt]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nmt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NMT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1nmt| PDB=1nmt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nmt OCA], [https://pdbe.org/1nmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nmt RCSB], [https://www.ebi.ac.uk/pdbsum/1nmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nmt ProSAT]</span></td></tr>
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</table>
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===N-MYRISTOYL TRANSFERASE FROM CANDIDA ALBICANS AT 2.45 A===
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== Function ==
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[https://www.uniprot.org/uniprot/NMT_CANAL NMT_CANAL] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8.<ref>PMID:1569105</ref> <ref>PMID:8300631</ref> <ref>PMID:9115247</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9501915 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nm/1nmt_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9501915}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1NMT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NMT OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nmt ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of the anti-fungal target N-myristoyl transferase., Weston SA, Camble R, Colls J, Rosenbrock G, Taylor I, Egerton M, Tucker AD, Tunnicliffe A, Mistry A, Mancia F, de la Fortelle E, Irwin J, Bricogne G, Pauptit RA, Nat Struct Biol. 1998 Mar;5(3):213-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501915 9501915]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Pauptit RA]]
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[[Category: Pauptit, R A.]]
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[[Category: Weston SA]]
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[[Category: Weston, S A.]]
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[[Category: Acyltransferase]]
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[[Category: Antifungal target]]
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[[Category: Coa]]
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[[Category: Myristylation]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:47:03 2008''
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Current revision

N-MYRISTOYL TRANSFERASE FROM CANDIDA ALBICANS AT 2.45 A

PDB ID 1nmt

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