2rka

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{{Seed}}
 
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[[Image:2rka.png|left|200px]]
 
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==The Structure of rat cytosolic PEPCK in complex with phosphoglycolate==
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The line below this paragraph, containing "STRUCTURE_2rka", creates the "Structure Box" on the page.
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<StructureSection load='2rka' size='340' side='right'caption='[[2rka]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RKA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
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{{STRUCTURE_2rka| PDB=2rka | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rka OCA], [https://pdbe.org/2rka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rka RCSB], [https://www.ebi.ac.uk/pdbsum/2rka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rka ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCKGC_RAT PCKGC_RAT] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rk/2rka_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rka ConSurf].
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<div style="clear:both"></div>
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===The Structure of rat cytosolic PEPCK in complex with phosphoglycolate===
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==See Also==
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*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18197707 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18197707}}
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==About this Structure==
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2RKA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKA OCA].
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==Reference==
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Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition., Stiffin RM, Sullivan SM, Carlson GM, Holyoak T, Biochemistry. 2008 Feb 19;47(7):2099-109. Epub 2008 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18197707 18197707]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Carlson GM]]
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[[Category: Carlson, G M.]]
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[[Category: Holyoak T]]
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[[Category: Holyoak, T.]]
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[[Category: Stiffin RM]]
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[[Category: Stiffin, R M.]]
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[[Category: Sullivan SM]]
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[[Category: Sullivan, S M.]]
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[[Category: Cytoplasm]]
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[[Category: Decarboxylase]]
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[[Category: Gluconeogenesis]]
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[[Category: Gtp-binding]]
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[[Category: Kinase]]
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[[Category: Lyase]]
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[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:49:17 2008''
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Current revision

The Structure of rat cytosolic PEPCK in complex with phosphoglycolate

PDB ID 2rka

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