1tjy

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{{Seed}}
 
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[[Image:1tjy.png|left|200px]]
 
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==Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF==
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The line below this paragraph, containing "STRUCTURE_1tjy", creates the "Structure Box" on the page.
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<StructureSection load='1tjy' size='340' side='right'caption='[[1tjy]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TJY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene></td></tr>
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{{STRUCTURE_1tjy| PDB=1tjy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjy OCA], [https://pdbe.org/1tjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tjy RCSB], [https://www.ebi.ac.uk/pdbsum/1tjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LSRB_SALTY LSRB_SALTY] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable).<ref>PMID:11722742</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tjy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial populations use cell-cell communication to coordinate community-wide regulation of processes such as biofilm formation, virulence, and bioluminescence. This phenomenon, termed quorum sensing, is mediated by small molecule signals known as autoinducers. While most autoinducers are species specific, autoinducer-2 (AI-2), first identified in the marine bacterium Vibrio harveyi, is produced and detected by many Gram-negative and Gram-positive bacteria. The crystal structure of the V. harveyi AI-2 signaling molecule bound to its receptor protein revealed an unusual furanosyl borate diester. Here, we present the crystal structure of a second AI-2 signal binding protein, LsrB from Salmonella typhimurium. We find that LsrB binds a chemically distinct form of the AI-2 signal, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (R-THMF), that lacks boron. Our results demonstrate that two different species of bacteria recognize two different forms of the autoinducer signal, both derived from 4,5-dihydroxy-2,3-pentanedione (DPD), and reveal new sophistication in the chemical lexicon used by bacteria in interspecies signaling.
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===Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF===
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Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2.,Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM Mol Cell. 2004 Sep 10;15(5):677-87. PMID:15350213<ref>PMID:15350213</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15350213}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1tjy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15350213 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15350213}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1TJY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJY OCA].
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Bassler BL]]
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==Reference==
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[[Category: Campagna SR]]
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Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2., Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM, Mol Cell. 2004 Sep 10;15(5):677-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15350213 15350213]
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[[Category: Hughson FM]]
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[[Category: Salmonella typhimurium lt2]]
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[[Category: Miller ST]]
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[[Category: Single protein]]
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[[Category: Semmelhack MF]]
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[[Category: Bassler, B L.]]
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[[Category: Taga ME]]
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[[Category: Campagna, S R.]]
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[[Category: Xavier KB]]
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[[Category: Hughson, F M.]]
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[[Category: Miller, S T.]]
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[[Category: Semmelhack, M F.]]
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[[Category: Taga, M E.]]
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[[Category: Xavier, K B.]]
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[[Category: Protein-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:50:16 2008''
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Current revision

Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF

PDB ID 1tjy

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