1pb1

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(New page: 200px<br /><applet load="1pb1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pb1, resolution 1.70&Aring;" /> '''A four location mode...)
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[[Image:1pb1.jpg|left|200px]]<br /><applet load="1pb1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pb1, resolution 1.70&Aring;" />
 
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'''A four location model to explain the stereospecificity of proteins.'''<br />
 
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==About this Structure==
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==A four location model to explain the stereospecificity of proteins.==
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1PB1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4, ICT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PB1 OCA].
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<StructureSection load='1pb1' size='340' side='right'caption='[[1pb1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PB1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ICT:ISOCITRIC+ACID'>ICT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pb1 OCA], [https://pdbe.org/1pb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pb1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDH_ECOLI IDH_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/1pb1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pb1 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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A new model for protein stereospecificity., Mesecar AD, Koshland DE Jr, Nature. 2000 Feb 10;403(6770):614-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10688187 10688187]
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*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Isocitrate dehydrogenase (NADP(+))]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Koshland Jr DE]]
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[[Category: Jr., D.E.Koshland.]]
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[[Category: Mesecar AD]]
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[[Category: Mesecar, A.D.]]
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[[Category: GOL]]
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[[Category: ICT]]
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[[Category: SO4]]
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[[Category: enantiomer]]
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[[Category: isocitrate dehydrogenase]]
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[[Category: l-isocitrate]]
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[[Category: specificity]]
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[[Category: stereospecificity]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:39:05 2007''
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Current revision

A four location model to explain the stereospecificity of proteins.

PDB ID 1pb1

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