1pbo

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(New page: 200px<br /><applet load="1pbo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pbo, resolution 2.2&Aring;" /> '''COMPLEX OF BOVINE ODO...)
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[[Image:1pbo.jpg|left|200px]]<br /><applet load="1pbo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1pbo, resolution 2.2&Aring;" />
 
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'''COMPLEX OF BOVINE ODORANT BINDING PROTEIN (OBP) WITH A SELENIUM CONTAINING ODORANT'''<br />
 
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==Overview==
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==COMPLEX OF BOVINE ODORANT BINDING PROTEIN (OBP) WITH A SELENIUM CONTAINING ODORANT==
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Odorant binding protein (OBP) is the major odorant binding component of, mammalian nasal mucosa. The two structures of bovine OBP reported in this, paper (one crystallized as purified and one soaked in the presence of a, selenium-containing odorant) show that: (i) the OBP dimer is composed of, two compact domains related by an approximate two-fold axis of symmetry;, (ii) between residues 122 and 123 the polypeptide chains cross from one, domain to the other such that each domain is formed by residues from both, monomers; (iii) purified OBP already contains two bound odorant molecules, (one per monomer)-odorant binding occurs by replacement of these molecules, with the added odorant; and (iv) the structure of the odorant binding site, can explain OBP's extraordinarily broad odorant specificity.
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<StructureSection load='1pbo' size='340' side='right'caption='[[1pbo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pbo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PBO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SES:4-BUTYL-5-PROPYL-1,3-SELENAZOL-2-AMINE'>SES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pbo OCA], [https://pdbe.org/1pbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pbo RCSB], [https://www.ebi.ac.uk/pdbsum/1pbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pbo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OBP_BOVIN OBP_BOVIN] This protein binds a wide variety of chemical odorants.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/1pbo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pbo ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1PBO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SES as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PBO OCA].
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*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition., Bianchet MA, Bains G, Pelosi P, Pevsner J, Snyder SH, Monaco HL, Amzel LM, Nat Struct Biol. 1996 Nov;3(11):934-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8901871 8901871]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Amzel, L.M.]]
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[[Category: Amzel LM]]
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[[Category: Bains, G.]]
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[[Category: Bains G]]
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[[Category: Bianchet, M.A.]]
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[[Category: Bianchet MA]]
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[[Category: Monaco, H.]]
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[[Category: Monaco H]]
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[[Category: SES]]
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[[Category: lipocalin]]
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[[Category: odorant-binding]]
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[[Category: transport]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:40:09 2007''
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Current revision

COMPLEX OF BOVINE ODORANT BINDING PROTEIN (OBP) WITH A SELENIUM CONTAINING ODORANT

PDB ID 1pbo

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