2ecs

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{{Seed}}
 
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[[Image:2ecs.png|left|200px]]
 
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==Lambda Cro mutant Q27P/A29S/K32Q at 1.4 A in space group C2==
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The line below this paragraph, containing "STRUCTURE_2ecs", creates the "Structure Box" on the page.
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<StructureSection load='2ecs' size='340' side='right'caption='[[2ecs]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ecs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2ecs| PDB=2ecs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecs OCA], [https://pdbe.org/2ecs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecs RCSB], [https://www.ebi.ac.uk/pdbsum/2ecs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecs ProSAT]</span></td></tr>
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</table>
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===Lambda Cro mutant Q27P/A29S/K32Q at 1.4 A in space group C2===
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== Function ==
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[https://www.uniprot.org/uniprot/RCRO_LAMBD RCRO_LAMBD] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18054042}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18054042 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecs_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18054042}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2ECS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecs ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA., Hall BM, Roberts SA, Heroux A, Cordes MH, J Mol Biol. 2008 Jan 18;375(3):802-11. Epub 2007 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18054042 18054042]
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</StructureSection>
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[[Category: Enterobacteria phage lambda]]
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[[Category: Escherichia virus Lambda]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cordes, M H.]]
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[[Category: Cordes MH]]
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[[Category: Hall, B M.]]
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[[Category: Hall BM]]
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[[Category: Roberts, S A.]]
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[[Category: Roberts SA]]
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[[Category: Bacteriophage]]
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[[Category: Flexibility]]
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[[Category: Helix-turn-helix]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:14:28 2008''
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Current revision

Lambda Cro mutant Q27P/A29S/K32Q at 1.4 A in space group C2

PDB ID 2ecs

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