2io8

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{{Seed}}
 
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[[Image:2io8.png|left|200px]]
 
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<!--
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==E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and ADP==
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The line below this paragraph, containing "STRUCTURE_2io8", creates the "Structure Box" on the page.
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<StructureSection load='2io8' size='340' side='right'caption='[[2io8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2io8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IO8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2io8| PDB=2io8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2io8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2io8 OCA], [https://pdbe.org/2io8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2io8 RCSB], [https://www.ebi.ac.uk/pdbsum/2io8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2io8 ProSAT]</span></td></tr>
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</table>
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===E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and ADP===
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== Function ==
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[https://www.uniprot.org/uniprot/GSP_ECOLI GSP_ECOLI] Catalyzes the formation of an amide bond between glutathione and spermidine coupled with hydrolysis of ATP; also catalyzes the hydrolysis of glutathionylspermidine to glutathione and spermidine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17124497}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17124497 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2io8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17124497}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2IO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IO8 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2io8 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase., Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH, EMBO J. 2006 Dec 13;25(24):5970-82. Epub 2006 Nov 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17124497 17124497]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chiang, B Y.]]
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[[Category: Chiang BY]]
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[[Category: Chong, C M.]]
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[[Category: Chong CM]]
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[[Category: Chou, C C.]]
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[[Category: Chou CC]]
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[[Category: Coward, J K.]]
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[[Category: Coward JK]]
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[[Category: Ko, T P.]]
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[[Category: Ko TP]]
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[[Category: Lin, C H.]]
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[[Category: Lin CH]]
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[[Category: Pai, C H.]]
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[[Category: Pai CH]]
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[[Category: Wang, A H.J.]]
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[[Category: Wang AH-J]]
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[[Category: Yen, F J.]]
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[[Category: Yen FJ]]
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[[Category: Bifunctional glutathionylspermidine synthetase/amidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:16:20 2008''
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Current revision

E. coli Bifunctional glutathionylspermidine synthetase/amidase Incomplex with Mg2+ and ADP

PDB ID 2io8

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