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1t77

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{{Seed}}
 
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[[Image:1t77.png|left|200px]]
 
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==Crystal structure of the PH-BEACH domains of human LRBA/BGL==
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The line below this paragraph, containing "STRUCTURE_1t77", creates the "Structure Box" on the page.
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<StructureSection load='1t77' size='340' side='right'caption='[[1t77]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t77]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T77 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t77 OCA], [https://pdbe.org/1t77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t77 RCSB], [https://www.ebi.ac.uk/pdbsum/1t77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t77 ProSAT]</span></td></tr>
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{{STRUCTURE_1t77| PDB=1t77 | SCENE= }}
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</table>
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== Disease ==
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===Crystal structure of the PH-BEACH domains of human LRBA/BGL===
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[https://www.uniprot.org/uniprot/LRBA_HUMAN LRBA_HUMAN] Defects in LRBA are the cause of immunodeficiency, common variable, type 8, with autoimmunity (CVID8) [MIM:[https://omim.org/entry/614700 614700]. An autosomal recessive immunologic disorder associated with defective B-cell differentiation and decreased or absent antibody production. Affected individuals have early-childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease.<ref>PMID:22608502</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/LRBA_HUMAN LRBA_HUMAN] May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity).
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_15554694}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15554694 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_15554694}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t77_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1T77 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T77 OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t77 ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Crystal structure of the PH-BEACH domains of human LRBA/BGL., Gebauer D, Li J, Jogl G, Shen Y, Myszka DG, Tong L, Biochemistry. 2004 Nov 30;43(47):14873-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15554694 15554694]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gebauer, D.]]
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[[Category: Gebauer D]]
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[[Category: Jogl, G.]]
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[[Category: Jogl G]]
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[[Category: Li, J.]]
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[[Category: Li J]]
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[[Category: Myszka, D G.]]
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[[Category: Myszka DG]]
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[[Category: Shen, Y.]]
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[[Category: Shen Y]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Ph-beach domain]]
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[[Category: Signal transduction]]
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[[Category: Vesicle trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:16:25 2008''
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Current revision

Crystal structure of the PH-BEACH domains of human LRBA/BGL

PDB ID 1t77

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