2q73

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{{Seed}}
 
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[[Image:2q73.png|left|200px]]
 
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==Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212)==
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The line below this paragraph, containing "STRUCTURE_2q73", creates the "Structure Box" on the page.
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<StructureSection load='2q73' size='340' side='right'caption='[[2q73]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q73]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_sp._DAT722 Vibrio sp. DAT722]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q73 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2q73| PDB=2q73 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q73 OCA], [https://pdbe.org/2q73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q73 RCSB], [https://www.ebi.ac.uk/pdbsum/2q73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q73 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q2F9Z1_9VIBR Q2F9Z1_9VIBR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q73_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q73 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mobile gene cassettes collectively contain a highly diverse pool of novel genes that encode many novel adaptive functions. In the non-clinical context, the function of almost all of the encoded proteins remains unknown despite the enormous size of this mobile gene pool. We have been characterizing cassette arrays by taking advantage of the fact that they cluster at discrete sites in chromosomes; even large arrays are thus recoverable in a relatively small number of clones in genomic libraries. In one assembled array of 116 cassettes from the marine bacterium Vibrio sp. DAT722, a putative MazG protein is encoded within the 21st cassette. Because MazG proteins are implicated in a number of cellular processes, including house-cleaning and stress survival, the presence of such a protein in a mobile cassette was noteworthy. Here we solve the crystal structure of this alpha-helical protein, and define both open and closed states of a new variant of the MazG family. Functional assays confirm that the protein is a dNTP pyrophosphohydrolase, with marked preferences for dCTP and dATP. We hypothesize that iMazG acts as a house-cleaning enzyme, preventing the incorporation of damaging non-canonical nucleotides into host-cell DNA.
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===Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212)===
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A putative house-cleaning enzyme encoded within an integron array: 1.8 A crystal structure defines a new MazG subtype.,Robinson A, Guilfoyle AP, Harrop SJ, Boucher Y, Stokes HW, Curmi PM, Mabbutt BC Mol Microbiol. 2007 Nov;66(3):610-21. Epub 2007 Sep 24. PMID:17892463<ref>PMID:17892463</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17892463}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2q73" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17892463 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17892463}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2Q73 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_sp._dat722 Vibrio sp. dat722]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q73 OCA].
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[[Category: Vibrio sp. DAT722]]
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[[Category: Boucher Y]]
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==Reference==
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[[Category: Curmi PMG]]
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A putative house-cleaning enzyme encoded within an integron array: 1.8 A crystal structure defines a new MazG subtype., Robinson A, Guilfoyle AP, Harrop SJ, Boucher Y, Stokes HW, Curmi PM, Mabbutt BC, Mol Microbiol. 2007 Nov;66(3):610-21. Epub 2007 Sep 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17892463 17892463]
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[[Category: Guilfoyle AP]]
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[[Category: Nucleoside-triphosphate diphosphatase]]
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[[Category: Harrop SJ]]
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[[Category: Single protein]]
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[[Category: Mabbutt BC]]
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[[Category: Vibrio sp. dat722]]
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[[Category: Robinson A]]
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[[Category: Boucher, Y.]]
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[[Category: Stokes HW]]
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[[Category: Curmi, P M.G.]]
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[[Category: Guilfoyle, A P.]]
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[[Category: Harrop, S J.]]
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[[Category: Mabbutt, B C.]]
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[[Category: Robinson, A.]]
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[[Category: Stokes, H W.]]
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[[Category: Hydrolase]]
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[[Category: Mazg]]
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[[Category: Ntp-ppase]]
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[[Category: Vibrio]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:19:25 2008''
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Current revision

Crystal structure of iMazG from Vibrio DAT 722: Ctag-iMazG (P41212)

PDB ID 2q73

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