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1xaj

From Proteopedia

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{{Seed}}
 
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[[Image:1xaj.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE==
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The line below this paragraph, containing "STRUCTURE_1xaj", creates the "Structure Box" on the page.
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<StructureSection load='1xaj' size='340' side='right'caption='[[1xaj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xaj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRB:[1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC+ACID'>CRB</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1xaj| PDB=1xaj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xaj OCA], [https://pdbe.org/1xaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xaj RCSB], [https://www.ebi.ac.uk/pdbsum/1xaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xaj ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE===
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== Function ==
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[https://www.uniprot.org/uniprot/AROB_STAAR AROB_STAAR]
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15465043}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15465043 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xaj_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15465043}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XAJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAJ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xaj ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases., Nichols CE, Ren J, Leslie K, Dhaliwal B, Lockyer M, Charles I, Hawkins AR, Stammers DK, J Mol Biol. 2004 Oct 22;343(3):533-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15465043 15465043]
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</StructureSection>
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[[Category: 3-dehydroquinate synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Charles, I.]]
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[[Category: Charles I]]
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[[Category: Dhaliwal, B.]]
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[[Category: Dhaliwal B]]
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[[Category: Hawkins, A R.]]
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[[Category: Hawkins AR]]
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[[Category: Leslie, K.]]
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[[Category: Leslie K]]
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[[Category: Lockyer, M.]]
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[[Category: Lockyer M]]
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[[Category: Nichols, C E.]]
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[[Category: Nichols CE]]
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[[Category: Ren, J.]]
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[[Category: Ren J]]
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[[Category: Stammers, D K.]]
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[[Category: Stammers DK]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Closed form]]
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[[Category: Cyclase]]
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[[Category: Dhq]]
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[[Category: Domain movement]]
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[[Category: Form b]]
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[[Category: Lyase]]
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[[Category: Sadhq]]
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[[Category: Shikimate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:23:21 2008''
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Current revision

CRYSTAL STRUCTURE OF STAPHLYOCOCCUS AUREUS 3-DEHYDROQUINATE SYNTHASE (DHQS) IN COMPLEX WITH ZN2+, NAD+ AND CARBAPHOSPHONATE

PDB ID 1xaj

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