1wn4

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{{Seed}}
 
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[[Image:1wn4.png|left|200px]]
 
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==NMR Structure of VoNTR==
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The line below this paragraph, containing "STRUCTURE_1wn4", creates the "Structure Box" on the page.
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<StructureSection load='1wn4' size='340' side='right'caption='[[1wn4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Viola_odorata Viola odorata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WN4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wn4 OCA], [https://pdbe.org/1wn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1wn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wn4 ProSAT]</span></td></tr>
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{{STRUCTURE_1wn4| PDB=1wn4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VARA_VIOOD VARA_VIOOD] Probably participates in a plant defense mechanism. Has hemolytic activity.[PROSITE-ProRule:PRU00395]<ref>PMID:16872274</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cyclotides are the largest family of naturally occurring circular proteins. The mechanism by which the termini of these gene-encoded proteins are linked seamlessly with a peptide bond to form a circular backbone is unknown. Here we report cyclotide-encoding cDNA sequences from the plant Viola odorata and compare them with those from an evolutionarily distinct species, Oldenlandia affinis. Individual members of this multigene family encode one to three mature cyclotide domains. These domains are preceded by N-terminal repeat regions (NTRs) that are conserved within a plant species but not between species. We have structurally characterized peptides corresponding to these NTRs and show that, despite them having no sequence homology, they form a structurally conserved alpha-helical motif. This structural conservation suggests a vital role for the NTR in the in vivo folding, processing, or detoxification of cyclotide domains from the precursor protein.
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===NMR Structure of VoNTR===
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Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins.,Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ J Biol Chem. 2004 Nov 5;279(45):46858-67. Epub 2004 Aug 24. PMID:15328347<ref>PMID:15328347</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15328347}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wn4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15328347 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15328347}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN4 OCA].
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[[Category: Viola odorata]]
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[[Category: Anderson MA]]
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==Reference==
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[[Category: Clark RJ]]
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Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins., Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ, J Biol Chem. 2004 Nov 5;279(45):46858-67. Epub 2004 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15328347 15328347]
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[[Category: Craik DJ]]
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[[Category: Anderson, M A.]]
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[[Category: Daly NL]]
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[[Category: Clark, R J.]]
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[[Category: Dutton JL]]
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[[Category: Craik, D J.]]
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[[Category: Jennings CV]]
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[[Category: Daly, N L.]]
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[[Category: Renda RF]]
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[[Category: Dutton, J L.]]
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[[Category: Waine C]]
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[[Category: Jennings, C V.]]
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[[Category: Renda, R F.]]
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[[Category: Waine, C.]]
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[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:27:19 2008''
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Current revision

NMR Structure of VoNTR

PDB ID 1wn4

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