1z9h

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{{Seed}}
 
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[[Image:1z9h.png|left|200px]]
 
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==Microsomal prostaglandin E synthase type-2==
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The line below this paragraph, containing "STRUCTURE_1z9h", creates the "Structure Box" on the page.
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<StructureSection load='1z9h' size='340' side='right'caption='[[1z9h]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z9h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z9H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene></td></tr>
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{{STRUCTURE_1z9h| PDB=1z9h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9h OCA], [https://pdbe.org/1z9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z9h RCSB], [https://www.ebi.ac.uk/pdbsum/1z9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z9h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGES2_MACFA PGES2_MACFA] Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z9h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z9h ConSurf].
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<div style="clear:both"></div>
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===Microsomal prostaglandin E synthase type-2===
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==See Also==
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*[[Prostaglandin E synthase|Prostaglandin E synthase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15854652}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15854652 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15854652}}
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==About this Structure==
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1Z9H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9H OCA].
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==Reference==
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Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2)., Yamada T, Komoto J, Watanabe K, Ohmiya Y, Takusagawa F, J Mol Biol. 2005 May 20;348(5):1163-76. Epub 2005 Apr 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15854652 15854652]
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[[Category: Macaca fascicularis]]
[[Category: Macaca fascicularis]]
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[[Category: Prostaglandin-E synthase]]
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[[Category: Komoto J]]
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[[Category: Single protein]]
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[[Category: Ohmiya Y]]
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[[Category: Komoto, J.]]
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[[Category: Takusagawa F]]
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[[Category: Ohmiya, Y.]]
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[[Category: Watanabe K]]
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[[Category: Takusagawa, F.]]
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[[Category: Yamada T]]
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[[Category: Watanabe, K.]]
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[[Category: Yamada, T.]]
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[[Category: Indomethacin]]
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[[Category: Membran associated protein]]
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[[Category: Prostaglandin e synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:34:49 2008''
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Current revision

Microsomal prostaglandin E synthase type-2

PDB ID 1z9h

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