1zyo

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{{Seed}}
 
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[[Image:1zyo.png|left|200px]]
 
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==Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein==
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The line below this paragraph, containing "STRUCTURE_1zyo", creates the "Structure Box" on the page.
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<StructureSection load='1zyo' size='340' side='right'caption='[[1zyo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1zyo| PDB=1zyo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [https://pdbe.org/1zyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [https://www.ebi.ac.uk/pdbsum/1zyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9EB08_9VIRU Q9EB08_9VIRU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zyo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sesbania mosaic virus (SeMV) polyprotein is processed by its N-terminal serine protease domain. The crystal structure of the protease domain was determined to a resolution of 2.4 A using multiple isomorphous replacement and anomalous scattering. The SeMV protease domain exhibited the characteristic trypsin fold and was found to be closer to cellular serine proteases than to other viral proteases. The residues of the S1-binding pocket, H298, T279 and N308 were mutated to alanine in the DeltaN70-Protease-VPg polyprotein, and the cis-cleavage activity was examined. The H298A and T279A mutants were inactive, while the N308A mutant was partially active, suggesting that the interactions of H298 and T279 with P1-glutamate are crucial for the E-T/S cleavage. A region of exposed aromatic amino acids, probably essential for interaction with VPg, was identified on the protease domain, and this interaction could play a major role in modulating the function of the protease.
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===Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein===
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Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocket.,Gayathri P, Satheshkumar PS, Prasad K, Nair S, Savithri HS, Murthy MR Virology. 2006 Mar 15;346(2):440-51. Epub 2005 Dec 13. PMID:16356524<ref>PMID:16356524</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16356524}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zyo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16356524 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16356524}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ZYO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA].
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==Reference==
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Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocket., Gayathri P, Satheshkumar PS, Prasad K, Nair S, Savithri HS, Murthy MR, Virology. 2006 Mar 15;346(2):440-51. Epub 2005 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16356524 16356524]
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[[Category: Glutamyl endopeptidase]]
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[[Category: Sesbania mosaic virus]]
[[Category: Sesbania mosaic virus]]
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[[Category: Single protein]]
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[[Category: Gayathri P]]
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[[Category: Gayathri, P.]]
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[[Category: Murthy MRN]]
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[[Category: Murthy, M R.N.]]
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[[Category: Prasad K]]
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[[Category: Prasad, K.]]
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[[Category: Satheshkumar PS]]
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[[Category: Satheshkumar, P S.]]
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[[Category: Savithri HS]]
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[[Category: Savithri, H S.]]
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[[Category: Beta-barrel]]
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[[Category: Glutamyl endopeptidase]]
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[[Category: Viral serine protease of trypsin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:39:55 2008''
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Current revision

Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein

PDB ID 1zyo

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