1wkw

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{{Seed}}
 
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[[Image:1wkw.png|left|200px]]
 
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==Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide==
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The line below this paragraph, containing "STRUCTURE_1wkw", creates the "Structure Box" on the page.
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<StructureSection load='1wkw' size='340' side='right'caption='[[1wkw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene></td></tr>
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{{STRUCTURE_1wkw| PDB=1wkw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkw OCA], [https://pdbe.org/1wkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkw RCSB], [https://www.ebi.ac.uk/pdbsum/1wkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wkw ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16271312}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16271312 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16271312}}
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==About this Structure==
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1WKW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKW OCA].
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==Reference==
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Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods., Tomoo K, Matsushita Y, Fujisaki H, Abiko F, Shen X, Taniguchi T, Miyagawa H, Kitamura K, Miura K, Ishida T, Biochim Biophys Acta. 2005 Dec 1;1753(2):191-208. Epub 2005 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16271312 16271312]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Fujisaki, H.]]
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[[Category: Fujisaki H]]
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[[Category: Ishida, T.]]
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[[Category: Ishida T]]
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[[Category: Kitamura, K.]]
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[[Category: Kitamura K]]
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[[Category: Matsushita, Y.]]
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[[Category: Matsushita Y]]
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[[Category: Miura, K.]]
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[[Category: Miura K]]
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[[Category: Miyagawa, H.]]
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[[Category: Miyagawa H]]
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[[Category: Shen, X.]]
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[[Category: Shen X]]
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[[Category: Tomoo, K.]]
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[[Category: Tomoo K]]
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[[Category: Cap-binding protein]]
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[[Category: Initiation factor]]
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[[Category: Mrna-cap]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:41:12 2008''
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Current revision

Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide

PDB ID 1wkw

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