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1tbp

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{{Seed}}
 
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[[Image:1tbp.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA==
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The line below this paragraph, containing "STRUCTURE_1tbp", creates the "Structure Box" on the page.
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<StructureSection load='1tbp' size='340' side='right'caption='[[1tbp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tbp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbp OCA], [https://pdbe.org/1tbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbp RCSB], [https://www.ebi.ac.uk/pdbsum/1tbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbp ProSAT]</span></td></tr>
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{{STRUCTURE_1tbp| PDB=1tbp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbp ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA===
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==See Also==
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*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8367480}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8367480 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_8367480}}
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==About this Structure==
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1TBP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBP OCA].
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==Reference==
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Crystal structure of yeast TATA-binding protein and model for interaction with DNA., Chasman DI, Flaherty KM, Sharp PA, Kornberg RD, Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8174-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8367480 8367480]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Chasman DI]]
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[[Category: Chasman, D I.]]
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[[Category: Flaherty KM]]
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[[Category: Flaherty, K M.]]
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[[Category: Kornberg RD]]
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[[Category: Kornberg, R D.]]
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[[Category: Sharp PA]]
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[[Category: Sharp, P A.]]
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[[Category: Binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:07:10 2008''
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Current revision

CRYSTAL STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA

PDB ID 1tbp

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