2f3x

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{{Seed}}
 
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[[Image:2f3x.png|left|200px]]
 
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==Crystal structure of FapR (in complex with effector)- a global regulator of fatty acid biosynthesis in B. subtilis==
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The line below this paragraph, containing "STRUCTURE_2f3x", creates the "Structure Box" on the page.
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<StructureSection load='2f3x' size='340' side='right'caption='[[2f3x]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f3x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLC:MALONYL-COENZYME+A'>MLC</scene></td></tr>
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{{STRUCTURE_2f3x| PDB=2f3x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3x OCA], [https://pdbe.org/2f3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3x RCSB], [https://www.ebi.ac.uk/pdbsum/2f3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3x ProSAT]</span></td></tr>
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</table>
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===Crystal structure of FapR (in complex with effector)- a global regulator of fatty acid biosynthesis in B. subtilis===
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== Function ==
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[https://www.uniprot.org/uniprot/FAPR_BACSU FAPR_BACSU] Transcription factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. Binds to the 5'-TTAGTANNNNNTANTAA-3' consensus sequence found in the promoter of fabHAF operon (containing fabHA and fabF genes), yhdO and fapR genes and prevents their expression. Its action is probably modulated by malonyl-CoA.<ref>PMID:12737802</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16932747}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16932747 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3x_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16932747}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2F3X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3X OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3x ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structural basis of lipid biosynthesis regulation in Gram-positive bacteria., Schujman GE, Guerin M, Buschiazzo A, Schaeffer F, Llarrull LI, Reh G, Vila AJ, Alzari PM, de Mendoza D, EMBO J. 2006 Sep 6;25(17):4074-83. Epub 2006 Aug 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16932747 16932747]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Alzari, P M.]]
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[[Category: Alzari PM]]
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[[Category: Buschiazzo, A.]]
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[[Category: Buschiazzo A]]
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[[Category: Guerin, M E.]]
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[[Category: Guerin ME]]
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[[Category: Hot-dog fold / malonyl-coa complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:10:48 2008''
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Current revision

Crystal structure of FapR (in complex with effector)- a global regulator of fatty acid biosynthesis in B. subtilis

PDB ID 2f3x

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