Template:STRUCTURE 2nvk

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2nvk, resolution 2.40Å ()

Ligands:

Gene:

Trxr-1 (Drosophila melanogaster)

Activity:

Thioredoxin-disulfide reductase, with EC number 1.8.1.9

Structural annotation:
Resources:	InterPro : Ipr001327, Ipr000815, Ipr012999, Ipr004099, Ipr013027, Ipr006338, Ipr001100 Pfam : PF02852, PF00070, PF07992 UniProt : P91938

Functional annotation:
Cellular component:	mitochondrion cytoplasm
Biological process:	thioredoxin pathway cell redox homeostasis electron transport determination of adult life span
Molecular function:	oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor thioredoxin-disulfide reductase activity FAD binding oxidoreductase activity antioxidant activity protein binding NADP binding glutathione-disulfide reductase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/Template:STRUCTURE_2nvk"

@@ Line 1: / Line 1: @@
-{{StructureD
+{{Structure
-|PDB= {{{PDB}}}|SCENE={{{SCENE}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|2nvk, resolution 2.40&Aring; (<scene name='initialview01'>initial scene</scene>)}}}
+|PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[2nvk]], [[Resolution|resolution]] 2.40&Aring; (<scene name='initialview01'>default scene</scene>)}}}
 |LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>
 |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span>
 |GENE= Trxr-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00070 Pyr_redox], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02852 Pyr_redox_dim], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK06116 PRK06116], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05329 PRK05329]</span>
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2nvk RCSB], [http://www.ebi.ac.uk/pdbsum/2nvk PDBsum]</span>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvk OCA], [http://www.ebi.ac.uk/pdbsum/2nvk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nvk RCSB]</span>
 |FUNCTION={{GO|id=GO:0016654 | text = oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor}}{{GO|id=GO:0004791 | text = thioredoxin-disulfide reductase activity}}{{GO|id=GO:0050660 | text = FAD binding}}{{GO|id=GO:0016491 | text = oxidoreductase activity}}{{GO|id=GO:0016209 | text = antioxidant activity}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0050661 | text = NADP binding}}{{GO|id=GO:0004362 | text = glutathione-disulfide reductase activity}}
 |PROCESS={{GO|id=GO:0006125 | text = thioredoxin pathway}}{{GO|id=GO:0045454 | text = cell redox homeostasis}}{{GO|id=GO:0006118 | text = electron transport}}{{GO|id=GO:0008340 | text = determination of adult life span}}
 |COMPONENT={{GO|id=GO:0005739 | text = mitochondrion}}{{GO|id=GO:0005737 | text = cytoplasm}}
 |SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001327 Ipr001327], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR000815 Ipr000815], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR012999 Ipr012999], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR004099 Ipr004099], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR013027 Ipr013027], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR006338 Ipr006338], [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001100 Ipr001100]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF02852 PF02852], [http://pfam.sanger.ac.uk/family?acc=PF00070 PF00070], [http://pfam.sanger.ac.uk/family?acc=PF07992 PF07992]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P91938 P91938]</span>
+|uPDB=2NVK|CONSURF={{!}}-
+{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]]
+{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;"
+{{!}} '''Toggle Conservation Colors:'''
+{{!}} align="left" style="background-color:#acfaac;border-top:2px solid #dddddd; border-right:2px solid #dddddd" {{!}}
+Rows = identical sequences:
+<jmol>
+<jmolButton>
+<script></script>
+<text>A [x]</text>
+<name>jmb_2nvk_A</name>
+<title>toggle chain A</title>
+<jsscript>ConsurfChainButton(elementClicked)</jsscript>
+<appendtargetsuffixtoid>true</appendtargetsuffixtoid>
+</jmolButton>
+</jmol>
 }}

Template:STRUCTURE 2nvk

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