2pp0

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{{Seed}}
 
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[[Image:2pp0.png|left|200px]]
 
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==Crystal structure of L-talarate/galactarate dehydratase from Salmonella typhimurium LT2==
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The line below this paragraph, containing "STRUCTURE_2pp0", creates the "Structure Box" on the page.
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<StructureSection load='2pp0' size='340' side='right'caption='[[2pp0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2pp0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PP0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2pp0| PDB=2pp0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp0 OCA], [https://pdbe.org/2pp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pp0 RCSB], [https://www.ebi.ac.uk/pdbsum/2pp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp0 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of L-talarate/galactarate dehydratase from Salmonella typhimurium LT2===
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== Function ==
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[https://www.uniprot.org/uniprot/TAGAD_SALTY TAGAD_SALTY] Catalyzes the efficient dehydration of both L-talarate and galactarate to 5-keto-4-deoxy-D-glucarate. Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L-talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars.<ref>PMID:17649980</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17649980}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17649980 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pp/2pp0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17649980}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2PP0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pp0 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2., Yew WS, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA, Biochemistry. 2007 Aug 21;46(33):9564-77. Epub 2007 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17649980 17649980]
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<references/>
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[[Category: Salmonella typhimurium]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Fedorov, A A.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Fedorov, E V.]]
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[[Category: Almo SC]]
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[[Category: Gerlt, J A.]]
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[[Category: Fedorov AA]]
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[[Category: Yew, W S.]]
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[[Category: Fedorov EV]]
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[[Category: Crystal structure]]
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[[Category: Gerlt JA]]
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[[Category: Enolase superfamily]]
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[[Category: Yew WS]]
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[[Category: L-talarate/galactarate dehydratase]]
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[[Category: Lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:24:56 2008''
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Current revision

Crystal structure of L-talarate/galactarate dehydratase from Salmonella typhimurium LT2

PDB ID 2pp0

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