1tmk

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{{Seed}}
 
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[[Image:1tmk.png|left|200px]]
 
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==YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)==
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The line below this paragraph, containing "STRUCTURE_1tmk", creates the "Structure Box" on the page.
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<StructureSection load='1tmk' size='340' side='right'caption='[[1tmk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TMK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
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{{STRUCTURE_1tmk| PDB=1tmk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tmk OCA], [https://pdbe.org/1tmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tmk RCSB], [https://www.ebi.ac.uk/pdbsum/1tmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tmk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_YEAST KTHY_YEAST] Catalyzes the conversion of dTMP to dTDP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tm/1tmk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tmk ConSurf].
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<div style="clear:both"></div>
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===YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)===
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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==About this Structure==
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__TOC__
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1TMK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TMK OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation., Lavie A, Vetter IR, Konrad M, Goody RS, Reinstein J, Schlichting I, Nat Struct Biol. 1997 Aug;4(8):601-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9253404 9253404]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Lavie A]]
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[[Category: DTMP kinase]]
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[[Category: Schlichting I]]
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[[Category: Lavie, A.]]
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[[Category: Schlichting, I.]]
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[[Category: Enzyme]]
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[[Category: Kinase]]
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[[Category: Thymidine activation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:26:58 2008''
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Current revision

YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)

PDB ID 1tmk

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