2gwm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:30, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2gwm.png|left|200px]]
 
-
<!--
+
==Crystal structure of the Salmonella SpvB ATR Domain==
-
The line below this paragraph, containing "STRUCTURE_2gwm", creates the "Structure Box" on the page.
+
<StructureSection load='2gwm' size='340' side='right'caption='[[2gwm]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2gwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GWM FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2gwm| PDB=2gwm | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwm OCA], [https://pdbe.org/2gwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gwm RCSB], [https://www.ebi.ac.uk/pdbsum/2gwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gwm ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of the Salmonella SpvB ATR Domain===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/SPVB_SALTM SPVB_SALTM] Mono-ADP-ribosylates eukaryotic muscle and non-muscle actin on 'Arg-177'. ADP-ribosylates all actins tested, has more activity on nonmuscle beta/gamma-actin than on muscle alpha-actin. Prefers monomeric G-actin but can weakly ADP-ribosylate F-actin. ADP-ribosylation prevents the polymerization of G-actin to F-actin, causing actin filament depolymerization, destruction of the cytoskeleton and cytotoxicity. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes.<ref>PMID:10972829</ref> <ref>PMID:16430223</ref> <ref>PMID:16905096</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_16905096}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16905096 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/2gwm_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_16905096}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
2GWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWM OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gwm ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
A steric antagonism of actin polymerization by a salmonella virulence protein., Margarit SM, Davidson W, Frego L, Stebbins CE, Structure. 2006 Aug;14(8):1219-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16905096 16905096]
+
<references/>
-
[[Category: Salmonella typhimurium]]
+
__TOC__
-
[[Category: Single protein]]
+
</StructureSection>
-
[[Category: Margarit, S M.]]
+
[[Category: Large Structures]]
-
[[Category: Stebbins, C E.]]
+
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-
[[Category: Adp-ribosyltransferase]]
+
[[Category: Margarit SM]]
-
[[Category: Salmonella]]
+
[[Category: Stebbins CE]]
-
[[Category: Spvb]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:06:53 2008''
+

Current revision

Crystal structure of the Salmonella SpvB ATR Domain

PDB ID 2gwm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gwm"
Personal tools