1zx4

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{{Seed}}
 
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[[Image:1zx4.png|left|200px]]
 
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==Structure of ParB bound to DNA==
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The line below this paragraph, containing "STRUCTURE_1zx4", creates the "Structure Box" on the page.
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<StructureSection load='1zx4' size='340' side='right'caption='[[1zx4]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zx4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_P1 Escherichia virus P1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZX4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1zx4| PDB=1zx4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zx4 OCA], [https://pdbe.org/1zx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zx4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zx4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q38420_9CAUD Q38420_9CAUD]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zx4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zx4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The faithful inheritance of genetic information, which is essential for all organisms, requires accurate DNA partition (segregation) at cell division. In prokaryotes, partition is mediated by par systems, for which the P1 plasmid system of Escherichia coli is a prototype comprising a partition site and two proteins, ParA and ParB. To form the partition complex necessary for segregation, P1 ParB must recognize a complicated arrangement of A-box and B-box DNA motifs located on opposite ends of a sharply bent parS partition site of approximately 74 bp (refs 3-7). Here we describe structures of ParB bound to partition sites. ParB forms an asymmetric dimer with extended amino-terminal HTH (helix-turn-helix) domains that contact A-boxes. The two HTH domains emanate from a dimerized DNA-binding module composed of a six-stranded beta-sheet coiled-coil that binds B-boxes. Strikingly, these individual DNA-binding modules rotate freely about a flexible linker, enabling them to contact several arrangements of A- and B-boxes. Most notably, each DNA-binding element binds to and thus bridges adjacent DNA duplexes. These unique structural features of ParB explain how this protein can bind complex arrays of A- and B-box elements on adjacent DNA arms of the looped partition site.
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===Structure of ParB bound to DNA===
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Structures of ParB bound to DNA reveal mechanism of partition complex formation.,Schumacher MA, Funnell BE Nature. 2005 Nov 24;438(7067):516-9. PMID:16306995<ref>PMID:16306995</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16306995}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zx4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16306995 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16306995}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia virus P1]]
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1ZX4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p1 Enterobacteria phage p1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZX4 OCA].
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[[Category: Large Structures]]
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[[Category: Funnell BE]]
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==Reference==
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[[Category: Schumacher MA]]
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Structures of ParB bound to DNA reveal mechanism of partition complex formation., Schumacher MA, Funnell BE, Nature. 2005 Nov 24;438(7067):516-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16306995 16306995]
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[[Category: Enterobacteria phage p1]]
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[[Category: Single protein]]
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[[Category: Funnell, B E.]]
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[[Category: Schumacher, M A.]]
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[[Category: P1]]
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[[Category: Partition]]
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[[Category: Plasmid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:28:24 2008''
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Current revision

Structure of ParB bound to DNA

PDB ID 1zx4

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