2fm8

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{{Seed}}
 
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[[Image:2fm8.png|left|200px]]
 
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==Crystal Structure of the Salmonella Secretion Chaperone InvB in Complex with SipA==
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The line below this paragraph, containing "STRUCTURE_2fm8", creates the "Structure Box" on the page.
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<StructureSection load='2fm8' size='340' side='right'caption='[[2fm8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fm8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm8 OCA], [https://pdbe.org/2fm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm8 ProSAT]</span></td></tr>
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{{STRUCTURE_2fm8| PDB=2fm8 | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of the Salmonella Secretion Chaperone InvB in Complex with SipA===
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[https://www.uniprot.org/uniprot/SPAK_SALTY SPAK_SALTY] Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone SopA, SopE, SopE2 and SipA.<ref>PMID:16547027</ref> <ref>PMID:16507363</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 16507363 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fm8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16507363}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fm8 ConSurf].
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2FM8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM8 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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A common structural motif in the binding of virulence factors to bacterial secretion chaperones., Lilic M, Vujanac M, Stebbins CE, Mol Cell. 2006 Mar 3;21(5):653-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16507363 16507363]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Salmonella typhimurium]]
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[[Category: Large Structures]]
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[[Category: Lilic, M.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Stebbins, C E.]]
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[[Category: Lilic M]]
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[[Category: Vujanac, M.]]
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[[Category: Stebbins CE]]
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[[Category: Bacterial]]
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[[Category: Vujanac M]]
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[[Category: Chaperone]]
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[[Category: Protein folding]]
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[[Category: Salmonella]]
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[[Category: Translocation]]
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[[Category: Type iii secretion]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:29:40 2008''
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Current revision

Crystal Structure of the Salmonella Secretion Chaperone InvB in Complex with SipA

PDB ID 2fm8

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