1smc

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{{Seed}}
 
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[[Image:1smc.png|left|200px]]
 
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==Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.==
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The line below this paragraph, containing "STRUCTURE_1smc", creates the "Structure Box" on the page.
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<StructureSection load='1smc' size='340' side='right'caption='[[1smc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1smc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUT:DEOXYURIDINE-5-TRIPHOSPHATE'>DUT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_1smc| PDB=1smc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smc OCA], [https://pdbe.org/1smc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smc RCSB], [https://www.ebi.ac.uk/pdbsum/1smc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1smc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1smc ConSurf].
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<div style="clear:both"></div>
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===Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.===
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==See Also==
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*[[DUTPase 3D structures|DUTPase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15276840}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15276840 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15276840}}
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==About this Structure==
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1SMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA].
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==Reference==
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Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism., Chan S, Segelke B, Lekin T, Krupka H, Cho US, Kim MY, So M, Kim CY, Naranjo CM, Rogers YC, Park MS, Waldo GS, Pashkov I, Cascio D, Perry JL, Sawaya MR, J Mol Biol. 2004 Aug 6;341(2):503-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15276840 15276840]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Cascio D]]
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[[Category: DUTP diphosphatase]]
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[[Category: Chan S]]
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[[Category: Cascio, D.]]
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[[Category: Cho US]]
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[[Category: Chan, S.]]
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[[Category: Eisenberg D]]
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[[Category: Cho, U S.]]
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[[Category: Kim C-Y]]
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[[Category: Eisenberg, D.]]
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[[Category: Kim M-Y]]
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[[Category: Kim, C Y.]]
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[[Category: Krupka H]]
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[[Category: Kim, M Y.]]
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[[Category: Lekin T]]
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[[Category: Krupka, H.]]
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[[Category: Naranjo CM]]
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[[Category: Lekin, T.]]
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[[Category: Park MS]]
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[[Category: Naranjo, C M.]]
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[[Category: Pashkov I]]
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[[Category: Park, M S.]]
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[[Category: Perry JL]]
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[[Category: Pashkov, I.]]
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[[Category: Rogers YC]]
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[[Category: Perry, J L.]]
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[[Category: Sawaya MR]]
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[[Category: Rogers, Y C.]]
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[[Category: Segelke B]]
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[[Category: Sawaya, M R.]]
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[[Category: So M]]
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[[Category: Segelke, B.]]
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[[Category: Terwilliger TC]]
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[[Category: So, M.]]
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[[Category: Waldo GS]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Yeates TO]]
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[[Category: Terwilliger, T C.]]
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[[Category: Waldo, G S.]]
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[[Category: Yeates, T O.]]
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[[Category: Jelly-roll]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:44:09 2008''
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Current revision

Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.

PDB ID 1smc

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OCA

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